Application of HPLC to Investigate the Physicochemical Properties and Intestinal Permeability of Ketoprofen

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dc.authoridKAYNAK, Mustafa Sinan/0000-0003-2917-2407
dc.authorwosidKAYNAK, Mustafa Sinan/D-9453-2019
dc.contributor.authorKaynak, Mustafa Sinan
dc.contributor.authorCelebier, Mustafa
dc.contributor.authorAkgeyik, Emrah
dc.contributor.authorSahin, Selma
dc.contributor.authorAltinoz, Sacide
dc.date.accessioned2024-08-04T20:43:16Z
dc.date.available2024-08-04T20:43:16Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe main objective of this study was to investigate the effect of pH on the solubility and intestinal permeability of ketoprofen by using HPLC. Ketoprofen is a slightly soluble acidic drug, and its solubility in aqueous phase is affected by pH changes dramatically. However, there is no data in the literature to support whether this pH dependent water solubility of ketoprofen will influence its absorption/bioavailability. In this study, the distribution-coefficient (log D) of ketoprofen at various pH values between 4.5 and 7.5 were investigated using HPLC, and then it was made an attempt to correlate the log D values with the intestinal permeability values. For this reason, in vivo intestinal permeability studies were performed at pH 4.5 and pH 7.5. The concentrations of model and reference compounds and also the blank buffers passed though the rat intestine were analyzed by means of a validated HPLC method. A nonlinear relationship was found between the results of in vitro and in vivo studies indicating that the diffusion of ketoprofen was not only related with passive diffusion, but also could be related with active transport.en_US
dc.identifier.doi10.2174/1573412912666160422151409
dc.identifier.endpage79en_US
dc.identifier.issn1573-4129
dc.identifier.issn1875-676X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85024118303en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage72en_US
dc.identifier.urihttps://doi.org/10.2174/1573412912666160422151409
dc.identifier.urihttps://hdl.handle.net/11616/97894
dc.identifier.volume13en_US
dc.identifier.wosWOS:000393441800012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Pharmaceutical Analysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKetoprofenen_US
dc.subjectintestinal permeabilityen_US
dc.subjectHPLC (high-performance/pressure liquid chromatography)en_US
dc.subjectdiffusion coefficienten_US
dc.subjectacid dissociation constanten_US
dc.subjectphysicochemical propertiesen_US
dc.titleApplication of HPLC to Investigate the Physicochemical Properties and Intestinal Permeability of Ketoprofenen_US
dc.typeArticleen_US

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