Synthesis of polyhedral oligomeric silsesquioxane-n-acetylcysteine conjugate with click chemistry and ıts antioxidant response and biocompatibility
| dc.contributor.author | Karaca Açarı, İdil | |
| dc.contributor.author | Balcıoğlu, Sevgi | |
| dc.contributor.author | Ateş, Burhan | |
| dc.contributor.author | Köytepe, Süleyman | |
| dc.contributor.author | Yılmaz, İsmet | |
| dc.contributor.author | Seçkin, Turgay | |
| dc.date.accessioned | 2021-03-09T13:28:54Z | |
| dc.date.available | 2021-03-09T13:28:54Z | |
| dc.date.issued | 2020 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description | DOI: https://doi.org/10.17776/csj.688124 | en_US |
| dc.description.abstract | Abstract: In this study, polyhedral oligomeric silsesquioxane-N-acetylcysteine (POSS-NAC) conjugate as a potential antioxidant molecule was synthesized from N-acetylcysteine (NAC) and aminofunctional POSS structure by click chemistry. The chemical structures and thermal properties of the synthesised POSS-NAC conjugate was characterized by spectroscopic and thermal analysis techniques. The antioxidant capacity of the POSS-NAC conjugate was also determined by the 2,2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity and reducing power methods. According to the reducing power method, POSS-NAC structure has lower reducing activity than standard ascorbic acid and trolox (p<0.001). It was found from the ABTS radical scavenging activity results that the synthesized POSS-NAC conjugate had a significantly higher radical scavenging effect than the standards (p <0.001). Biocompatibility properties of the POSS-NAC structure were detected in vitro cell culture system with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test on L-929 mouse fibroblast cells. The synthesized POSS-NAC conjugate exhibits high antioxidant activity and good biocompatibility | en_US |
| dc.identifier.citation | AÇARI İ. K,BALCIOĞLU S,ATEŞ B,KÖYTEPE S,YILMAZ İ,SEÇKİN T (2020). Synthesis of polyhedral oligomeric silsesquioxane-n-acetylcysteine conjugate with click chemistry and ıts antioxidant response and biocompatibility. Cumhuriyet Science Journal, 41(2), 386 - 396. Doi: 10.17776/csj.688124 | en_US |
| dc.identifier.doi | 10.17776/csj.688124 | en_US |
| dc.identifier.endpage | 396 | en_US |
| dc.identifier.issn | 2587-2680 | |
| dc.identifier.issn | 2587-246X | |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.startpage | 386 | en_US |
| dc.identifier.trdizinid | 386672 | en_US |
| dc.identifier.uri | https://doi.org/10.17776/csj.688124 | |
| dc.identifier.uri | https://hdl.handle.net/11616/19553 | |
| dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/386672 | |
| dc.identifier.volume | 41 | en_US |
| dc.indekslendigikaynak | TR-Dizin | en_US |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Cumhuriyet Science Journal | en_US |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Synthesis of polyhedral oligomeric silsesquioxane-n-acetylcysteine conjugate with click chemistry and ıts antioxidant response and biocompatibility | en_US |
| dc.type | Article | en_US |
