Copper-catalyzed azide-alkyne cycloaddition (CuAAC) under mild condition in water: Synthesis, catalytic application and biological activities

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dc.authoridTouj, Nedra/0000-0001-6071-4361
dc.authoridYaşar, Sedat/0000-0001-7285-2761
dc.authoridTouj, Nedra/0000-0001-6071-4361
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authoridHarrath, Abdel Halim/0000-0002-2170-1303
dc.authorwosidTouj, Nedra/G-6828-2019
dc.authorwosidMansour, Lamjed/AAD-8613-2019
dc.authorwosidAl-Tamimi, Jameel H/F-2374-2019
dc.authorwosidYaşar, Sedat/ABG-8356-2020
dc.authorwosidTouj, Nedra/AAM-2982-2021
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidMansour, Lamjed/U-3028-2017
dc.contributor.authorTouj, N.
dc.contributor.authorChakchouk-Mtibaa, A.
dc.contributor.authorMansour, L.
dc.contributor.authorHarrath, A. H.
dc.contributor.authorAl-Tamimi, J. H.
dc.contributor.authorOzdemir, I.
dc.contributor.authorMellouli, L.
dc.date.accessioned2024-08-04T20:44:05Z
dc.date.available2024-08-04T20:44:05Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA series of Cu-N-heterocyclic carbene (Cu-NHC) complexes, 3a-c, were synthesized and characterized by spectroscopic methods such as NMR, HRMS and elemental analysis. The performance of these (Cu-NHC) complexes, 3a-c showed excellent activity in 1,3-dipolar cycloaddition reactions between alkynes and azides to obtain 1,4-disubstituted triazoles 6a-d in 80%-91% isolated yields. All obtained complexes especially compounds 3a and 3c, presented significant inhibitory activity against the tested food-borne pathogens and clinical microorganisms. The compound 3a presents against S. aureus a MIC value of 4.8 mg/ml quite similar to that of ampicillin (4 mg/ml) used as standard. Compounds 3a and 3b, from a concentration of 0.5 mg/ml, present an identical scavenging activity to that of the two used controls butylated hydroxytoluene (BHT) and gallic acid (GA). Concerning acetylcholinesterase inhibition activity (AChEI), compound 6a presents an interesting AChEI activity with 68.3% of inhibition. (C) 2017 Published by Elsevier B.V.en_US
dc.description.sponsorshipDeanship of Scientific Research at King Saud University [RG-1435-023]en_US
dc.description.sponsorshipThe authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for its funding this research group No (RG-1435-023).en_US
dc.identifier.doi10.1016/j.jorganchem.2017.09.024
dc.identifier.endpage63en_US
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-85032380983en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2017.09.024
dc.identifier.urihttps://hdl.handle.net/11616/98012
dc.identifier.volume853en_US
dc.identifier.wosWOS:000417654800008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCopper N-heterocyclic carbene complexen_US
dc.subjectAlkynesen_US
dc.subjectAzidesen_US
dc.subjectClick chemistryen_US
dc.subjectHomogeneous catalysisen_US
dc.subjectBiological activitiesen_US
dc.titleCopper-catalyzed azide-alkyne cycloaddition (CuAAC) under mild condition in water: Synthesis, catalytic application and biological activitiesen_US
dc.typeArticleen_US

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