Possible role of nitric oxide and adrenomedullin in bipolar affective disorder

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564;
dc.authorwosidCengiz, Beyhan/F-6044-2011
dc.authorwosidUz, Efkan/B-2943-2016
dc.authorwosidZoroglu, Salih/ABD-8029-2020
dc.authorwosidzoroglu, suleyman s/B-2077-2012
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosidCengiz, Beyhan/AAC-8976-2022
dc.contributor.authorSavas, HA
dc.contributor.authorHerken, H
dc.contributor.authorYürekli, M
dc.contributor.authorUz, E
dc.contributor.authorTutkun, H
dc.contributor.authorZoroglu, SS
dc.contributor.authorÖzen, ME
dc.date.accessioned2024-08-04T20:12:21Z
dc.date.available2024-08-04T20:12:21Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNitric oxide (NO) has been implicated to play a role in the pathogenesis of depressive disorders. Adrenomedullin (AM) induces vasorelaxation by activating adenylate cyclase and also by stimulating the release of NO. AM immune reactivity is present in the brain, consistent with a role as neurotransmitter. Therefore, it is suggested that these two molecules may play a role together in the brain. We aimed to examine AM and NO in bipolar affective disorder (BPAD). Forty-four patients with BPAD and 21 healthy control subjects were included in this study. DSM-IV diagnosis of bipolar affective disorder (type 1, manic episodes) was independently established by two psychiatrists and the Turkish version of the Bech-Rafaelson Mania Scale was administered. Also, a semistructured form was used to ascertain several sociodemographic and clinical variables of the patients. AM and NO were studied in plasma. The mean value of plasma NO levels in the BPAD group of 46.58 +/- 13.97 mumol/l was significantly higher than that of controls (31.81 +/- 8.14 mumol/l) (z = -4.15, p = 0.000). Mean plasma AM levels were found to be increased in patients with BPAD (35.13 +/- 5.26 pmol/l) compared to controls (16.22 +/- 3.02 pmol/l) (z = -6.16, p = 0.000). AM levels of BPAD patients were approximately 2-fold higher than controls. AM levels were positively correlated with the duration of hospitalization for the current episode and negatively correlated with the total duration of illness. Both NO and AM may have a pathophysiological role in BPAD (type I, manic episodes) and the clinical symptomatology and prognosis of BPAD. Copyright (C) 2002 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000048677
dc.identifier.endpage61en_US
dc.identifier.issn0302-282X
dc.identifier.issn1423-0224
dc.identifier.issue2en_US
dc.identifier.pmid11893860en_US
dc.identifier.scopus2-s2.0-0036121050en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.1159/000048677
dc.identifier.urihttps://hdl.handle.net/11616/93380
dc.identifier.volume45en_US
dc.identifier.wosWOS:000174544800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofNeuropsychobiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectnitric oxideen_US
dc.subjectbipolar affective disorderen_US
dc.titlePossible role of nitric oxide and adrenomedullin in bipolar affective disorderen_US
dc.typeArticleen_US

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