The influence of atorvastatin on tendon healing: An experimental study on rabbits

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dc.authorscopusid56012788100
dc.authorscopusid8729399300
dc.authorscopusid24336523700
dc.authorscopusid6602951871
dc.authorscopusid35570759500
dc.contributor.authorEsenkaya I.
dc.contributor.authorSakarya B.
dc.contributor.authorUnay K.
dc.contributor.authorElmali N.
dc.contributor.authorAydin N.E.
dc.date.accessioned2024-08-04T19:59:16Z
dc.date.available2024-08-04T19:59:16Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHyperlipidemia is a major risk factor for coronary heart disease. The most commonly used antihyperlipidemic drugs are 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins), of which atorvastatin is one of the most widely used. Little is known about the relationship between tendinopathy and HMG CoA reductase inhibitors (statins) or the effects of atorvastatin use on tendon healing following surgical repair of tendon rupture. We hypothesized that atorvastatin negatively affects this healing process. The Achilles tendons of 16 New Zealand rabbits were ruptured surgically and repaired with sutures. Eight of the rabbits were given oral atorvastatin. The other 8 served as a surgical control group. Six weeks postoperatively, all the rabbits were sacrificed, and the repaired tendons were removed. After standard histological preparation, fibroblastic activity, revascularization, collagenization, collagen construction, and inflammatory-cell infiltration were evaluated. On comparing the atorvastatin and surgical control groups, we observed no difference in fibroblastic activity. Although it did not reach statistical significance in our study, a difference was noted in revascularization, collagenization, and inflammatory cell infiltration; and a statistical difference was observed in collagen construction. Doubt remains about the adverse effect of atorvastatin use during tendon healing. Further investigations in animal and human models are needed on the effects of tendon healing when atorvastatin is administered for a longer time frame prior to the injury.en_US
dc.identifier.doi10.3928/01477447-20100429-06
dc.identifier.issn0147-7447
dc.identifier.issue6en_US
dc.identifier.pmid20806777en_US
dc.identifier.scopus2-s2.0-77953647962en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3928/01477447-20100429-06
dc.identifier.urihttps://hdl.handle.net/11616/90511
dc.identifier.volume33en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofOrthopedicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectatorvastatinen_US
dc.subjectatorvastatinen_US
dc.subjectheptanoic acid derivativeen_US
dc.subjecthydroxymethylglutaryl coenzyme A reductase inhibitoren_US
dc.subjectpyrrole derivativeen_US
dc.subjectachilles tendon ruptureen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectarticleen_US
dc.subjectcell activityen_US
dc.subjectcell infiltrationen_US
dc.subjectcollagen synthesisen_US
dc.subjectcontrolled studyen_US
dc.subjectexperimental rabbiten_US
dc.subjectfibroblasten_US
dc.subjecthealingen_US
dc.subjecthealing impairmenten_US
dc.subjecthistopathologyen_US
dc.subjectinflammatory cellen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectpostoperative perioden_US
dc.subjectrevascularizationen_US
dc.subjecttendon sutureen_US
dc.subjectachilles tendonen_US
dc.subjectanimalen_US
dc.subjectcomparative studyen_US
dc.subjectdisease modelen_US
dc.subjectdose responseen_US
dc.subjectdrug effecten_US
dc.subjectinjuryen_US
dc.subjectmethodologyen_US
dc.subjectoral drug administrationen_US
dc.subjectorthopedic surgeryen_US
dc.subjectpathologyen_US
dc.subjectrabbiten_US
dc.subjecttendon injuryen_US
dc.subjecttreatment outcomeen_US
dc.subjectwound healingen_US
dc.subjectAchilles Tendonen_US
dc.subjectAdministration, Oralen_US
dc.subjectAnimalsen_US
dc.subjectDisease Models, Animalen_US
dc.subjectDose-Response Relationship, Drugen_US
dc.subjectHeptanoic Acidsen_US
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitorsen_US
dc.subjectMaleen_US
dc.subjectOrthopedic Proceduresen_US
dc.subjectPyrrolesen_US
dc.subjectRabbitsen_US
dc.subjectTendon Injuriesen_US
dc.subjectTreatment Outcomeen_US
dc.subjectWound Healingen_US
dc.titleThe influence of atorvastatin on tendon healing: An experimental study on rabbitsen_US
dc.typeArticleen_US

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