Oral administration of hesperidin, a citrus flavonone, in rats counteracts the oxidative stress, the inflammatory cytokine production, and the hepatotoxicity induced by the ingestion of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

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dc.authoridÇay, Mahmut/0000-0002-7757-055X
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridÇay, Mehmet/0000-0003-3896-0042
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidÇay, Mahmut/U-3399-2017
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidBentli, Recep/AAB-4140-2021
dc.authorwosidÇay, Mehmet/V-9584-2018
dc.authorwosidbasak, nese/ABH-5495-2020
dc.contributor.authorBentli, Recep
dc.contributor.authorCiftci, Osman
dc.contributor.authorCetin, Asli
dc.contributor.authorUnlu, Merve
dc.contributor.authorBasak, Nese
dc.contributor.authorCay, Mahmut
dc.date.accessioned2024-08-04T20:37:47Z
dc.date.available2024-08-04T20:37:47Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe objective of the current study was to investigate the protective effects of hesperidin against oxidative stress, altered cytokines levels and histological changes in rats induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Rats were divided randomly into four equal groups (Control, TCDD, hesperidin and TCDD+hesperidin). TCDD and hesperidin were given by gavage, dissolved in corn oil at doses of 2 mu/kg/week and 50 mg/kg/day respectively. The blood and tissue samples were taken from all rats on the 60th day, to be analyzed for the determination of oxidative stress, histological changes and cytokine levels. The results indicated that hesperidin prevented oxidative damage caused by TCDD via decrease lipid peroxidation and increased antioxidant defense systems. It also reversed the histological damage induced by TCDD. Although, TCDD led to a significant increase in TNF-alpha and IL-1 beta levels, hesperidin treatment was able to normalize these values in rats. In conclusion, it was shown that TCDD caused adverse effects as regards cytokine levels, histological alterations and oxidative stress in rats. However, hesperidin treatment mitigated these toxic effects. These results suggest that hesperidin could play a protective role against TCDD toxicity.en_US
dc.identifier.doi10.1684/ecn.2013.0337
dc.identifier.endpage96en_US
dc.identifier.issn1952-4005
dc.identifier.issue2en_US
dc.identifier.pmid23823010en_US
dc.identifier.scopus2-s2.0-84883171595en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage91en_US
dc.identifier.urihttps://doi.org/10.1684/ecn.2013.0337
dc.identifier.urihttps://hdl.handle.net/11616/96188
dc.identifier.volume24en_US
dc.identifier.wosWOS:000324383200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohn Libbey Eurotext Ltden_US
dc.relation.ispartofEuropean Cytokine Networken_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTCDDen_US
dc.subjecthesperidinen_US
dc.subjectcytokineen_US
dc.subjectoxidative stressen_US
dc.subjecthistological alterationsen_US
dc.titleOral administration of hesperidin, a citrus flavonone, in rats counteracts the oxidative stress, the inflammatory cytokine production, and the hepatotoxicity induced by the ingestion of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)en_US
dc.typeArticleen_US

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