The effect of adrenomedullin (ADM) on tyrosine hydroxylase (TH) enzyme activity and blood pressure in cold exposed rats

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authoridYuksel, Sengul/0000-0002-7190-431X
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosidYuksel, Sengul/ABI-2182-2020
dc.contributor.authorYuksel, S
dc.contributor.authorYurekli, M
dc.date.accessioned2024-08-04T20:13:31Z
dc.date.available2024-08-04T20:13:31Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIt is known that, under stress conditions the hypothalamo-pituitary-adrenal (HPA) axis is stimulated and catecholamine production is increased. Adrenomedullin (ADM) is a novel peptide that elicits a long-vasorelaxation, and participates in blood pressure regulation via different mechanisms. In the present study, we investigated the administration of ADM on tyrosine hydroxylase (TH) enzyme activity in cold exposed rats. Four groups of Sprague-Dawley rats were studied for their TH enzyme activity in the adrenal medulla and hypothalamus. In addition to measuring blood pressure in these rats, TH enzyme activity in both the adrenal medulla and hypothalamus were examined in four groups of Sprague-Dawley rats: animals exposed to room temperature and cold stress (8degreesC, 48 h), and rats injected with ADM (1.0 nmol/kg, i.v.) alone and/or together with cold stress. TH activity was shown to be increased in cold treated groups and decreased in ADM and ADM + cold stress group. Our findings appear to suggest that external ADM application caused an opposite effect on the same system in rats, decreasing the activity of tyrosine hydroxylase (TH) enzyme activity. Furthermore, externally applied ADM was shown to produce its expected hypotensive effect in cold-stressed rats. Our results suggest that a possible explanation for the effects of ADM is that, the uptake of ADM under cold stress may effect TH activity in studied tissues.en_US
dc.identifier.doi10.1507/endocrj.50.553
dc.identifier.endpage559en_US
dc.identifier.issn0918-8959
dc.identifier.issn1348-4540
dc.identifier.issue5en_US
dc.identifier.pmid14614211en_US
dc.identifier.scopus2-s2.0-0344010171en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage553en_US
dc.identifier.urihttps://doi.org/10.1507/endocrj.50.553
dc.identifier.urihttps://hdl.handle.net/11616/93676
dc.identifier.volume50en_US
dc.identifier.wosWOS:000186621700009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapan Endocrine Socen_US
dc.relation.ispartofEndocrine Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectcold stressen_US
dc.subjectraten_US
dc.subjecttyrosine hydroxylaseen_US
dc.subjectblood pressureen_US
dc.titleThe effect of adrenomedullin (ADM) on tyrosine hydroxylase (TH) enzyme activity and blood pressure in cold exposed ratsen_US
dc.typeArticleen_US

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