Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes

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dc.authoridÜstün, Elvan/0000-0002-0587-7261
dc.authoridÖzdemir, Namık/0000-0003-3371-9874
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridSAHIN, Neslihan/0000-0003-1498-4170
dc.authoridOzdemir, Ismail/0000-0001-6325-0216
dc.authorwosidÜstün, Elvan/HJB-1157-2022
dc.authorwosidÖzdemir, Namık/J-6434-2015
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidŞAHİN, Neslihan/F-6402-2019
dc.contributor.authorUstun, Elvan
dc.contributor.authorSahin, Neslihan
dc.contributor.authorCelik, Cem
dc.contributor.authorTutar, Ugur
dc.contributor.authorOzdemir, Namik
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:50:51Z
dc.date.available2024-08-04T20:50:51Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMicroorganisms attach to surfaces and interfaces and form biofilms which create a sheltered area for host cell response. Therefore, biofilms provide troubles in fields such as medicine, food, and pharmaceuticals. Inhibition of formation of biofilms through hindering of quorum sensing could be a method for the production of new generation antibiotics. In this study, four new benzimidazole type NHC precursors (1-allyl-3-benzyl-5,6-dimethylbenzimidazolium chloride, 1-allyl-3-(2,4,6-trimethylbenzyl)-5,6-dimethylbenzimidazolium chloride, 1-allyl-3-(2,3,5,6-tetramethylbenzyl)-5,6-dimethylbenzimidazolium chloride, and 1-allyl-3-(2,3,4,5,6-pentamethylbenzyl)-5,6-dimethylbenzimidazolium chloride and Ag-NHC complexes of these molecules were synthesized and characterized by elemental analysis, FT-IR spectroscopy, H-1, and C-13{H-1} NMR spectroscopy, LC-MS, and single crystal crystallography. Antimicrobial and biofilm formation inhibition activities of the molecules were evaluated. In addition, the activities of the molecules were examined in detail by molecular docking analysis. According to the results obtained, higher activity was achieved with the complex molecules when compared with the benzimidazole derivative ligands.en_US
dc.description.sponsorshipScientific Research Projects Unit of Ondokuz Mays University [PYO.FEN.1906.19.001]; nonu University Research Fund [u-BAP:FBG-2021-2562]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Unit of Ondokuz Mays University (Project No: PYO.FEN.1906.19.001) and nonu University Research Fund (u-BAP:FBG-2021-2562).en_US
dc.identifier.doi10.1039/d1dt02003j
dc.identifier.endpage15412en_US
dc.identifier.issn1477-9226
dc.identifier.issn1477-9234
dc.identifier.issue42en_US
dc.identifier.pmid34647935en_US
dc.identifier.scopus2-s2.0-85118943371en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage15400en_US
dc.identifier.urihttps://doi.org/10.1039/d1dt02003j
dc.identifier.urihttps://hdl.handle.net/11616/100306
dc.identifier.volume50en_US
dc.identifier.wosWOS:000707138600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofDalton Transactionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic Carbeneen_US
dc.subjectBiofilm Formationen_US
dc.subjectStructural-Characterizationen_US
dc.subjectCrystal-Structuresen_US
dc.subjectEscherichia-Colien_US
dc.subjectSilver(I)en_US
dc.subjectProgramen_US
dc.titleSynthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexesen_US
dc.typeArticleen_US

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