Evaluation of vascular reactivity of young male hypogonadotrophic hypogonadism patients

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dc.authoridKutlu, Mustafa/0000-0003-1663-2523
dc.authoridKARA, BATUHAN/0000-0002-4179-4324
dc.authoridKepez, Alper/0000-0003-3868-3268
dc.authorwosidKutlu, Mustafa/IUQ-1861-2023
dc.authorwosidErmis, Necip/HJP-7061-2023
dc.authorwosidErmis, Necip/A-5184-2018
dc.authorwosidKARA, BATUHAN/AAL-1599-2020
dc.authorwosidKepez, Alper/A-6204-2018
dc.contributor.authorDeniz, Ferhat
dc.contributor.authorErmis, Necip
dc.contributor.authorKepez, Alper
dc.contributor.authorTuerk, Baris
dc.contributor.authorAkkoyunlu, Murat
dc.contributor.authorKara, Batuhan
dc.contributor.authorKutlu, Mustafa
dc.date.accessioned2024-08-04T20:32:14Z
dc.date.available2024-08-04T20:32:14Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe aimed to study the vascular reactivity of young male hypogonadal hypogonadism patients without any cardiovascular risk factors and compare these findings with the ones of age-matched healthy controls. Study population consisted of 26 young male hypogonadotrophic hypogonadism patients (20.9 +/- A 1.3 years) and 25 age-matched healthy male controls (21.8 +/- A 2.9 years, P = NS). In addition to detailed hormonal analysis, each subject underwent ultrasound study of right brachial artery. Vessel diameter was measured at rest, during reactive hyperemia [endothelium-dependent flow-mediated vasodilation (FMD)] and after sublingual nitroglycerin administration (endothelium-independent vasodilation). Both flow-mediated and endothelium-independent sublingual nitroglycerin mediated dilatation values of patients were higher compared to controls (12.98 +/- A 10.76% vs. 7.92 +/- A 1.96%, P = 0.003 and 21.44 +/- A 10.36% vs. 14.72 +/- A 3.57%, P = 0.023, respectively). Linear regression analysis revealed that only serum HDL levels (relative risk 2.94, 95% CI 0.12-0.66, P = 0.006) and baseline vessel diameter (relative risk -2.77, 95% CI -17.73 to -2.70, P = 0.009) were found to be independently associated with FMD values. Endogenous male sex hormones seem to exert negative effects on vascular reactivity parameters and much of their effects are indirect that is by the way of alteration on lipid profile.en_US
dc.identifier.doi10.1007/s10554-009-9505-7
dc.identifier.endpage40en_US
dc.identifier.issn1569-5794
dc.identifier.issn1573-0743
dc.identifier.issue1en_US
dc.identifier.pmid19757149en_US
dc.identifier.scopus2-s2.0-73449142145en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage35en_US
dc.identifier.urihttps://doi.org/10.1007/s10554-009-9505-7
dc.identifier.urihttps://hdl.handle.net/11616/94942
dc.identifier.volume26en_US
dc.identifier.wosWOS:000272870100005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Journal of Cardiovascular Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypogonadismen_US
dc.subjectBrachial artery ultrasounden_US
dc.subjectEndothelial dysfunctionen_US
dc.titleEvaluation of vascular reactivity of young male hypogonadotrophic hypogonadism patientsen_US
dc.typeArticleen_US

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