Graft-versus-host disease after living donor liver transplantation: an unpredictable troublesome complication for liver transplant centers

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridKutluturk, Koray/0000-0002-7030-4953
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidKutluturk, Koray/S-5493-2019
dc.authorwosidBarut, Bora/ABD-9882-2020
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.contributor.authorGonultas, Fatih
dc.contributor.authorAkbulut, Sami
dc.contributor.authorBarut, Bora
dc.contributor.authorKutluturk, Koray
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:46:59Z
dc.date.available2024-08-04T20:46:59Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective The aim of this study was to report on graft-versus-host disease (GvHD) following living donor liver transplantation (LDLT). Methods Between May 2002 and January 2019, a total of 2387 LT procedures were performed in our Liver Transplantation Institute. Seven patients (0.29%) were admitted to our outpatient clinic with signs and symptoms compatible with GvHD following LT. Demographic, clinical and histopathological characteristics of patients with GvHD were retrospectively evaluated. Results There were six male and one female patient aged from 18 months to 67 years. Acute GvHD was detected in six patients and chronic GvHD in one. Grade II GvHD was detected in six patients, and Grade IV was detected in one patient. Time from LT to GVHD ranged from 4 to 657 days (median: 59 days). Time from beginning of clinical findings to histopathological diagnosis ranged from 2 to 160 days (median: 7 days). Initial clinical manifestations were as follows: skin rash + diarrhea (n = 2), skin rash (n = 2), skin rash + flushing (n = 1), diarrhea (n = 1), and skin rash + fever (n = 1). Despite intensive treatments, five out of seven patients (71.4%) died due to sepsis (n = 4) and gastrointestinal hemorrhage (n = 1). The remaining two patients are still alive without complications. Conclusion GvHD is a life-threatening complication despite aggressive treatment. To achieve success in GvHD, preventive measures, early diagnosis, early initiation of treatment, antimicrobial prophylaxis, and proper supportive care should be ensured.en_US
dc.identifier.doi10.1097/MEG.0000000000001530
dc.identifier.endpage100en_US
dc.identifier.issn0954-691X
dc.identifier.issn1473-5687
dc.identifier.issue1en_US
dc.identifier.pmid31524772en_US
dc.identifier.scopus2-s2.0-85075960160en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://doi.org/10.1097/MEG.0000000000001530
dc.identifier.urihttps://hdl.handle.net/11616/99088
dc.identifier.volume32en_US
dc.identifier.wosWOS:000561350800016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal of Gastroenterology & Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiarrheaen_US
dc.subjectgraft versus host diseaseen_US
dc.subjectliver transplantationen_US
dc.subjectmortalityen_US
dc.subjectrashen_US
dc.subjectrisk factorsen_US
dc.titleGraft-versus-host disease after living donor liver transplantation: an unpredictable troublesome complication for liver transplant centersen_US
dc.typeArticleen_US

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