Modeling the effect of physical crosslinking degree of pH and temperature responsive poly(NIPAAm-co-VSA)/alginate IPN hydrogels on drug release behavior

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dc.contributor.authorBalan, Kaan Emre
dc.contributor.authorBoztepe, Cihangir
dc.contributor.authorKuenkuel, Asim
dc.date.accessioned2024-08-04T20:52:14Z
dc.date.available2024-08-04T20:52:14Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThere is a growing demand to design and development of hydrogel based stimuli responsive drug-delivery systems due to possess several advantages, namely high drug loading capacity, target specific delivery, biocompatibility, reduced drug toxicity and controlled drug release. Because their drug release behavior is dependent on many factors, it is very difficult to accurately characterize these behaviors. So, the characterization of drug loading and release behaviors is very important from an industrial and academic point of view. In this study, pH and temperature responsive poly(NIPAAm-co-VSA)/Alginate interpenetrating polymer network (IPN) hydrogel was synthesized by free radical polymerization in the presence of Poly(NIPA-co-VSA) nano gels. Na-Alginate natural polymer was used to physically cross-link the hydrogels with the Ca(2+ )ions. To obtain physically crosslinked hydrogel series at different rates, hydrogels were kept in various concentrations of CaCl2 solutions. The mechanical, chemical and morphological properties of obtained hydrogel series were characterized by compression test, FT-IR and SEM analysis techniques. As a result of the mechanical tests, it was determined that the fracture strengths varied between 137 and 830 kPa. The doxorubicin (DOX) loading capacities of the hydrogels were determined to be between 86 and 161 mg DOX/g polymer by the solution impregnation method. Their DOX release behavior have been investigated as a function of time, pH, temperature and physical cross -linking degree of hydrogel. Experimentally obtained and highly complex DOX release behaviors were success-fully modeled with the artificial neural network (ANN) technique.en_US
dc.description.sponsorshipInonu University Research Fund [FYL-2020-2091]en_US
dc.description.sponsorshipAcknowledgements This study was supported by the Inonu University Research Fund [Project number: FYL-2020-2091] .en_US
dc.identifier.doi10.1016/j.jddst.2022.103671
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85135713501en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2022.103671
dc.identifier.urihttps://hdl.handle.net/11616/100832
dc.identifier.volume75en_US
dc.identifier.wosWOS:000841245600004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStimuli-responsive hydrogelsen_US
dc.subjectDrug releaseen_US
dc.subjectSodium alginateen_US
dc.subjectModelingen_US
dc.subjectANNen_US
dc.titleModeling the effect of physical crosslinking degree of pH and temperature responsive poly(NIPAAm-co-VSA)/alginate IPN hydrogels on drug release behavioren_US
dc.typeArticleen_US

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