Right-lobe Liver Transplant From Donors With Gilbert Syndrome

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dc.authoridDAYANGAC, MURAT/0000-0002-1240-7233;
dc.authorwosidDAYANGAC, MURAT/I-5907-2015
dc.authorwosidPiskin, Turgut/HKV-8614-2023
dc.contributor.authorDemirbas, Tolga
dc.contributor.authorPiskin, Turgut
dc.contributor.authorDayangac, Murat
dc.contributor.authorYaprak, Onur
dc.contributor.authorAkyildiz, Murat
dc.contributor.authorTokat, Yaman
dc.contributor.authorYuzer, Yildiray
dc.date.accessioned2024-08-04T20:35:44Z
dc.date.available2024-08-04T20:35:44Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Donor safety is one of the most important aspects of living-donor liver transplant. The preoperative evaluation of candidates for such transplants essentially starts with serologic and biochemical analyses. However, some potential liver donors with normal liver function test results may have isolated mild hyperbilirubinemia (serum indirect bilirubin level > 20.5 mu mol/L [1.2 mg/dL]). Gilbert syndrome is an autosomal recessive condition that is a common cause of nonhemolytic unconjugated hyperbilirubinemia, and its prevalence is 3% to 10% in the healthy US population. Mild hyperbilirubinemia episodes are expected in people with Gilbert syndrome when they are exposed to physical stress, such as operative intervention or low energy intake. The liver morphologic findings of these individuals are normal; however, there is a debate on the use of people with Gilbert syndrome as living-liver donors. The purpose of this study was to assess the results of right-lobe living-donor hepatectomy of liver donors with Gilbert syndrome. Materials and Methods: Between 2004 and 2010, two hundred twenty-five living-donor liver transplants using right-lobe grafts were performed in our hospital. Donors with Gilbert syndrome were defined as those whose serum bilirubin level was greater than 20.5 mu mol/L (1.2 mg/dL). Six of 225 right-lobe living-donor liver transplants were performed using donors with Gilbert syndrome. Results: The median follow-up after transplant was 34 months (range, 18 to 51 mo). One week after the operation, the median bilirubin level for rightlobe liver donors was 34.5 mu mol/L (2.02 mg/dL) (range, 17.1 to 51.3 mu mol/L [1 to 3 mg/dL]), and the median prothrombin time (international normalized ratio) was 1.36 (range, 1.1 to 1.7). The median bilirubin level of the donors after 6 months was 29 mu mol/L (1.7 mg/dL) (range, 20.5 to 41 mu mol/L [1.2 to 2.4 mg/dL]). Conclusions: Living-donor liver transplant from Gilbert syndrome donors can be safely performed.en_US
dc.identifier.doi10.6002/ect.2011.0063
dc.identifier.endpage42en_US
dc.identifier.issn1304-0855
dc.identifier.issue1en_US
dc.identifier.pmid22309418en_US
dc.identifier.scopus2-s2.0-84856945802en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org/10.6002/ect.2011.0063
dc.identifier.urihttps://hdl.handle.net/11616/95565
dc.identifier.volume10en_US
dc.identifier.wosWOS:000302188500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaskent Univen_US
dc.relation.ispartofExperimental and Clinical Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiving-donor liver transplantationen_US
dc.subjectLiving-donoren_US
dc.subjectRight hepatectomyen_US
dc.subjectGilbert syndromeen_US
dc.subjectHyperbilirubinemiaen_US
dc.titleRight-lobe Liver Transplant From Donors With Gilbert Syndromeen_US
dc.typeArticleen_US

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