Possible heart failure associated with pregabalin use: case report

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dc.authoridErdogan Kayhan, Gulay/0000-0002-2635-9295
dc.authorwosidErdogan Kayhan, Gulay/JVZ-0037-2024
dc.contributor.authorErdogan, Gulay
dc.contributor.authorCeyhan, Dilek
dc.contributor.authorGulec, Sacit
dc.date.accessioned2024-08-04T20:32:50Z
dc.date.available2024-08-04T20:32:50Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPregabalin and gabapentin are widely used analgesic, anticonvulsant and anxiolytic agents as they are relatively reliable and easily tolerated. However, they may cause some side effects such as dizziness, somnolence, dose-dependent peripheral edema, and weight gain, which may cause patients to abandon their use. Furthermore, there are a few reports in the literature addressing elderly patients with serious chronic disease and cardiac history, who develop heart failure during pregabalin application. In this report, we present a patient with no cardiac history treated with 300 mg/kg pregabalin due to neuropathic pain, who developed peripheral and then central edema, which were determined after advanced investigations. After stopping pregabalin, the situation regressed. Then, peripheral edema developed associated with the recommended dose of gabapentin, which was used in place of pregabalin. Despite the lack of any published evidence, the New York Heart Association issued a warning about using caution when prescribing pregabalin to type III-IV heart failure patients. Though the effect mechanisms of pregabalin and gabapentin are not well known, the calcium channel relationship may lead to these side effects. In summary, we believe that pregabalin and gabapentin, which is mostly used nowadays, should be administered with care not only in patients with advanced cardiac pathology but also in all patients, due to the potential side effects.en_US
dc.identifier.doi10.5505/agri.2011.35119
dc.identifier.endpage83en_US
dc.identifier.issn1300-0012
dc.identifier.issue2en_US
dc.identifier.pmid21644108en_US
dc.identifier.scopus2-s2.0-79957475750en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage80en_US
dc.identifier.urihttps://doi.org/10.5505/agri.2011.35119
dc.identifier.urihttps://hdl.handle.net/11616/95333
dc.identifier.volume23en_US
dc.identifier.wosWOS:000421197900006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofAgri-The Journal of The Turkish Society of Algologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHeart failureen_US
dc.subjectedemaen_US
dc.subjectpregabalinen_US
dc.titlePossible heart failure associated with pregabalin use: case reporten_US
dc.typeArticleen_US

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