Six-month clinical outcomes of non-surgical periodontal treatment with antibiotics on apoptosis markers in aggressive periodontitis

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dc.authoridAral, Cüneyt Asım/0000-0002-7366-345X
dc.authoridAral, Kubra/0000-0003-4798-4548
dc.authorwosidAral, Cüneyt Asım/AAA-3641-2020
dc.authorwosidAral, Cüneyt Asım/ABG-8668-2020
dc.authorwosidKapila, Yvonne/AAG-5418-2021
dc.authorwosidAral, Kubra/R-3039-2017
dc.contributor.authorAral, Kubra
dc.contributor.authorAral, Cuneyt A.
dc.contributor.authorKapila, Yvonne
dc.date.accessioned2024-08-04T20:45:41Z
dc.date.available2024-08-04T20:45:41Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective Extrinsic and intrinsic pathways of apoptosis are involved in generalized aggressive periodontitis (GAgP). The aim of this study was to evaluate 6-month clinical outcomes relative to apoptosis of one-stage full-mouth disinfection (OSFMD) and systemic antibiotics (SA) in the treatment of GAgP. Methods Twenty-six patients with GAgP were included in this prospective follow-up intervention study. Gingival crevicular fluid (GCF) was collected from patients at baseline and 3 and 6 months after periodontal therapy, which consisted of OSFMD and SA (amoxicillin and metronidazole, 500 mg each for 7 days). The levels of p53, caspase-3, TNF-alpha, TRAIL, IL-1 beta, and IL-10 in GCF were measured via ELISA. Results Periodontal parameters were improved at 3 and 6 months compared to baseline (p < 0.05). p53 was decreased up to 6 months (p < 0.05). TRAIL, TNF-alpha, and IL-10 were similar at baseline and 3 and 6 months. Caspase-3 and IL-1 beta were decreased at 3 months (p < 0.05), but similar at 6 months compared to baseline (p > 0.05). Conclusion Although OSFMD plus SA improves clinical periodontal parameters up to 6 months, this treatment protocol differentially regulates the apoptosis markers caspase-3 at 3 months and p53 at 6 months without influencing TRAIL in GCF.en_US
dc.identifier.doi10.1111/odi.13032
dc.identifier.endpage847en_US
dc.identifier.issn1354-523X
dc.identifier.issn1601-0825
dc.identifier.issue3en_US
dc.identifier.pmid30614174en_US
dc.identifier.scopus2-s2.0-85060820037en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage839en_US
dc.identifier.urihttps://doi.org/10.1111/odi.13032
dc.identifier.urihttps://hdl.handle.net/11616/98629
dc.identifier.volume25en_US
dc.identifier.wosWOS:000461858600024en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofOral Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapoptosisen_US
dc.subjectcaspase-3en_US
dc.subjectperiodontitisen_US
dc.subjectTNF-related apoptosis-inducing liganden_US
dc.subjecttumor necrosis factor-alphaen_US
dc.subjecttumor suppressor protein p53en_US
dc.titleSix-month clinical outcomes of non-surgical periodontal treatment with antibiotics on apoptosis markers in aggressive periodontitisen_US
dc.typeArticleen_US

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