Predictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomas

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dc.contributor.authorÇiçin, İrfan
dc.contributor.authorÖzatlı, Tahsin
dc.contributor.authorTürkmen, Esma
dc.contributor.authorÖztürk, Türkan
dc.contributor.authorÖzçelik, Melike
dc.contributor.authorÇabuk, Devrim
dc.contributor.authorGökdurnalı, Ayşe
dc.contributor.authorBalvan, Özlem
dc.contributor.authorYıldız, Yaşar
dc.contributor.authorŞeker, Metin
dc.contributor.authorÖzdemir, Nuriye
dc.contributor.authorYapar, Burcu
dc.contributor.authorTanrıverdi, Özgür
dc.contributor.authorGünaydın, Yusuf
dc.contributor.authorMenekşe, Serkan
dc.contributor.authorÖksüzoğlu, Berna
dc.contributor.authorAksoy, Asude
dc.contributor.authorHacıoğlu, M. Bekir
dc.contributor.authorErdoğan, Bülent
dc.contributor.authorArpacı, Erkan
dc.contributor.authorSevinç, Alper
dc.date.accessioned2021-11-30T13:54:48Z
dc.date.available2021-11-30T13:54:48Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAbstract: Background: Prognostic factors and the standard treatment approach for gynaecological carcinosarco-mas have not yet been clearly defined. Although car-cinosarcomas are more aggressive than pure epithelial tumours, they are treated similarly. Serous/clear cell and endometrioid components may be predictive fac-tors for the efficacy of adjuvant chemotherapy (CT) or radiotherapy (RT) or RT in patients with uterine and ovarian carcinosarcomas. Heterologous carcino-sarcomas may benefit more from adjuvant CT.Aims: We aimed to define the prognostic and predic-tive factors associated with treatment options in ovar-ian (OCS) and uterine carcinosarcoma (UCS).Study Design: Retrospective cross-sectional studyMethods: We retrospectively reviewed the medical re-cords of patients with ovarian and uterine carcinosar-coma from 2000 to 2013, and 127 women were includ-ed in this study (24 ovarian and 103 uterine). Patients admitted to seventeen oncology centres in Turkey be-tween 2000 and December 2013 with a histologically proven diagnosis of uterine carcinosarcoma with FIGO 2009 stage I-III and patients with sufficient data ob-tained from well-kept medical records were included in this study. Stage IV tumours were excluded. The pa-tient records were retrospectively reviewed. Data from 104 patients were evaluated for this study.Results: Age (>=70 years) was a poor prognostic factor for UCS (p=0.036). Pelvic±para aortic lymph node dis-section did not affect overall survival (OS) (p=0.35). Macroscopic residual disease was related with OS (p<0.01). The median OS was significantly longer in stage I-II patients than stage III patients (p=0.03). Adjuvant treatment improved OS (p=0.013). Adju-vant radiotherapy tended to increase the median OSen_US
dc.identifier.citationÇİÇİN İ,ÖZATLI T,TÜRKMEN E,Öztürk T,ÖZÇELİK M,ÇABUK D,GÖKDURNALI A,BALVAN Ö,YILDIZ Y,ŞEKER M,ÖZDEMİR N,YAPAR B,TANRIVERDİ Ö,GÜNAYDIN Y,MENEKŞE S,ÖKSÜZOĞLU B,AKSOY A,ERDOĞAN B,HACIOĞLU M. B,ARPACI E,SEVİNÇ A (2016). Predictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomas. Balkan Medical Journal, 33(5), 517 - 524.en_US
dc.identifier.endpage524en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue5en_US
dc.identifier.startpage517en_US
dc.identifier.trdizinid204560en_US
dc.identifier.urihttps://hdl.handle.net/11616/43555
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/204560
dc.identifier.volume33en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePredictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomasen_US
dc.typeArticleen_US

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