Microscopic Portal Vein Invasion in Relation to Tumor Focality and Dimension in Patients with Hepatocellular Carcinoma

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dc.authoridince, volkan/0000-0002-0714-490X
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridCarr, Brian/0000-0002-6111-5077
dc.authoridDonghia, Rossella/0000-0002-9140-673X
dc.authoridIsik, Burak/0000-0002-2395-3985
dc.authorwosidince, volkan/M-7325-2017
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.contributor.authorCarr, Brian, I
dc.contributor.authorGuerra, Vito
dc.contributor.authorDonghia, Rossella
dc.contributor.authorInce, Volkan
dc.contributor.authorAkbulut, Sami
dc.contributor.authorErsan, Veysel
dc.contributor.authorUsta, Sertac
dc.date.accessioned2024-08-04T20:50:41Z
dc.date.available2024-08-04T20:50:41Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Microscopic portal vein invasion (microPVI) and tumor multifocality are hepatocellular carcinoma (HCC) prognosis factors. To investigate whether microPVI and multifocality are directly related to each other. Methods We retrospectively analyzed the relationships between microPVI, multifocality, and maximum tumor diameter (MTD) in prospectively collected transplanted HCC patients. Results HCCs with 1, 2, or >= 3 foci had more microPVI in larger than in smaller HCCs, with microPVI being present in 52.24% of single large foci. Conversely, microPVI patients had similar percentages of single and multifocal lesions. A linear regression model of MTD, showed microPVI best associated with MTD, with 2.49 as coefficient, whereas multifocality had a 0.83 coefficient. A logistic regression model of microPVI showed significant association with tumor multifocality, especially for small HCCs. Trends for microPVI and multifocality in relation to MTD revealed that both increased with MTD but more significantly for microPVI. Survival was similar in patients with small HCCs, with or without microPVI, but was significantly worse in microPVI patients with larger HCCs. No patient survival differences were found in relation to focality. Conclusions MTD had stronger associations with microPVI than with multifocality. microPVI was associated with worse survival in patients with large HCCs, but survival was not impacted by number of tumor foci. microPVI and multifocality appear weakly related, having different behavior in relation to MTD and survival.en_US
dc.description.sponsorshipNIH [CA 82723]en_US
dc.description.sponsorshipThis work was supported in part by NIH grant CA 82723 (B.I.C).en_US
dc.identifier.doi10.1007/s11605-021-05126-7
dc.identifier.endpage340en_US
dc.identifier.issn1091-255X
dc.identifier.issn1873-4626
dc.identifier.issue2en_US
dc.identifier.pmid34506030en_US
dc.identifier.scopus2-s2.0-85114662931en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage333en_US
dc.identifier.urihttps://doi.org/10.1007/s11605-021-05126-7
dc.identifier.urihttps://hdl.handle.net/11616/100199
dc.identifier.volume26en_US
dc.identifier.wosWOS:000694783300008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectMicroscopic portal vein invasionen_US
dc.subjectFocalityen_US
dc.subjectSurvivalen_US
dc.titleMicroscopic Portal Vein Invasion in Relation to Tumor Focality and Dimension in Patients with Hepatocellular Carcinomaen_US
dc.typeArticleen_US

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