The roles of thiol oxidoreductases in yeast replicative aging
Yükleniyor...
Dosyalar
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mechanisms of Ageing and Development
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as
protection against oxidative stress, signal transduction and protein folding. Some proteins involved in
redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess
the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of
yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several
pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and
degradation, peroxide reduction, PIP3 signaling, and ATP synthesis.
Açıklama
Mechanisms of Ageing and Development 131 (2010) 692–699.
Anahtar Kelimeler
Oxidoreductase, Antioxidant, Oxidation, Aging, Life span
Kaynak
Mechanisms of Ageing and Development
WoS Q Değeri
Scopus Q Değeri
Cilt
131
Sayı
11-12
Künye
Elise, H., ESMER DEMİRCİ, I., Dmitri E, F., Vadim N, G., & KOÇ, A. (2010). The Roles Of Thiol Oxidoreductases İn Yeast Replicative Aging. Mechanisms Of Ageing And Development, 131(11-12), 692–699.
