Melatonin's protective effect on the salivary gland against ionized radiation damage in rats

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridGurocak, Asc Prof Simay/0000-0002-3707-5183
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridSIMSEK, GOKCE/0000-0001-5281-0986
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidGurocak, Asc Prof Simay/N-3351-2014
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidSIMSEK, GOKCE/F-1019-2016
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.contributor.authorKaraer, Isil Cakmak
dc.contributor.authorSimsek, Gokce
dc.contributor.authorYildiz, Azibe
dc.contributor.authorVardi, Nigar
dc.contributor.authorPolat, Alaadin
dc.contributor.authorTanbek, Kevser
dc.contributor.authorGurocak, Simay
dc.date.accessioned2024-08-04T20:42:41Z
dc.date.available2024-08-04T20:42:41Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectivesThe aim of this study was to examine the effects of melatonin on ionized radiation-induced salivary gland damage using an experimental model. Materials and MethodsThirty-two rats were randomized into four groups: (i) the control group (C, n = 8) that received intraperitoneal (i.p.) 0.9% NaCl; (ii) the melatonin group (M, n = 8) that received i.p. 5 mg/kg melatonin; (iii) the radiotherapy group (RT, n = 8) that underwent irradiation; (iv) the melatonin plus radiotherapy group (M+RT, n = 8) that received i.p. 5 mg/kg of melatonin, followed by irradiation 30 min later; and (v) the radiotherapy plus melatonin group (RT+M, n = 8) that received irradiation followed by i.p. 5 mg/kg of melatonin 30 min later. The medications and irradiation were administered for 5 days and the salivary glands of the rats were excised 10 days later; the histopathological changes in the salivary glands were assessed and biochemical analyses were conducted (tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI)). ResultsRegardless of whether melatonin was administered before or after radiotherapy, melatonin decreased the radiation-induced parotid and submandibular histological damage. In addition, regardless of whether administration occurred before or after radiotherapy, melatonin decreased oxidative stress markers, such as MDA, TOS, and OSI. On the contrary, levels of antioxidative markers, such as CAT and GPx, were increased by melatonin. ConclusionsMelatonin may have a significant protective effect on salivary gland damage secondary to ionizing radiation.en_US
dc.identifier.doi10.1111/jop.12386
dc.identifier.endpage449en_US
dc.identifier.issn0904-2512
dc.identifier.issn1600-0714
dc.identifier.issue6en_US
dc.identifier.pmid26757153en_US
dc.identifier.scopus2-s2.0-84990172936en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage444en_US
dc.identifier.urihttps://doi.org/10.1111/jop.12386
dc.identifier.urihttps://hdl.handle.net/11616/97522
dc.identifier.volume45en_US
dc.identifier.wosWOS:000379928800009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Oral Pathology & Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmelatoninen_US
dc.subjectoxidative stressen_US
dc.subjectradiotherapyen_US
dc.subjectsalivary glanden_US
dc.titleMelatonin's protective effect on the salivary gland against ionized radiation damage in ratsen_US
dc.typeArticleen_US

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