Antioxidant effect of sildenafil on cadmium-induced liver, lung and kidney injury

Basit Öğe Kaydı
dc.authorscopusid57216658627
dc.authorscopusid57214865784
dc.authorscopusid8911442500
dc.authorscopusid6603643064
dc.contributor.authorBaran A.H.
dc.contributor.authorBerk A.
dc.contributor.authorKaymaz M.B.
dc.contributor.authorAktay G.
dc.date.accessioned2024-08-04T20:01:01Z
dc.date.available2024-08-04T20:01:01Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study is to investigate the protective effect of sildenafil against cadmium-induced liver, lung and kidney toxicity. In total of 28 Sprague Dawley female rats included in this study were divided into four groups: control, Sil, Cd, Sil+Cd groups. CdCl2 and Sil citrate were dissolved in distilled water, the injection volume adjusted to 0,5 ml / rat. On the 7th day, a single dose of 3,7 mg/kg Cd was injected ip in the morning and Sil was administered in drinking water for 10 days. On the 10th day of the experiment, 72 hours after Cd administration, the rats were sacrificed under anesthesia and the lungs, kidneys and livers of the rats were isolated and Thiobarbituric acid reactive substances (TBARs), GSH, total thiol (T-SH) levels in these tissues were evaluated. Tissue damage was assessed by serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, blood urea nitrogen (BUN) and creatine kinase (CK-MB). It was found that cadmium significantly increased AST, ALT, creatinine, BUN, CK-MB and TBARs levels compared to the control group, and significantly decreased GSH andT-SH levels. In sildenafil + cadmium administration, TBARs levels significantly decreased while GSH and T-SH levels significantly increased compared to cadmium group. The protective effect of sildenafil against multiple organ damage caused by cadmium may be due to its antioxidant properties. © 2020 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.en_US
dc.identifier.endpage44en_US
dc.identifier.issn1300-4182
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85084234899en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://hdl.handle.net/11616/91197
dc.identifier.volume45en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSociety of Pharmaceutical Sciences of Ankara (FABAD)en_US
dc.relation.ispartofFabad Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant systemen_US
dc.subjectCadmiumen_US
dc.subjectHeavy metal toxicityen_US
dc.subjectInflammationen_US
dc.subjectOxidative stressen_US
dc.subjectSildenafilen_US
dc.titleAntioxidant effect of sildenafil on cadmium-induced liver, lung and kidney injuryen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu