Association between serum uric acid levels and chronic tension-type headache: A case–control study

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dc.contributor.authorAlgul, Fatma Ebru
dc.contributor.authorKablan, Yuksel
dc.date.accessioned2026-04-04T13:19:00Z
dc.date.available2026-04-04T13:19:00Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground: Tension-type headache (TTH) is the most common type of primary headache. Its etiology has not been clearly elucidated, and conflicting results have been reported in studies on oxidative stress. Uric acid is a molecule with antioxidant properties and is the end product of purine catabolism. Total oxidant-antioxidant status may potentially play an important role in the pathophysiology of chronic TTH. In this study, we investigated whether there was a difference in uric acid levels, an oxidative stress marker, between patients with tension-type headache and healthy controls. Methods: The study was designed retrospective observational case–control study. The diagnosis of chronic TTH was made according to the diagnostic criteria established by the International Classification of Headache Disorders. A total of 164 people, including 94 patients with chronic tension-type headache and 70 healthy controls were included in the study. Hemoglobin, blood urea nitrogen (BUN), creatinine, albumin, and serum uric acid levels were studied from the serum of the participants. The Kolmogorov Smirnov Normality test, Mann–Whitney U test, and binary logistic regression test were used for statistical analysis. Results: There was no statistically significant difference between our control and patient groups in terms of age and BUN (p = 0.069 and p = 0.547). The serum albumin (p = 0.000), creatinine (p = 0.047), and hemoglobin levels (p = 0.000) in our patient group were found to be significantly low compared to the healthy control group. The serum uric acid levels in the TTH and control groups were 4.28 ± 1.16 and 5.32 ± 1.31 mg/dL, respectively (p = 0.000). Lower uric acid levels correlate with an increased likelihood of TTH presence in both males and females. Conclusion: We demonstrated that serum uric acid levels in TTH patients were lower than in controls. Further studies with larger populations are needed to determine whether uric acid plays a protective role in the etiology of TTH by reducing oxidative stress. © The Author(s) 2024.
dc.identifier.doi10.1177/25158163241308795
dc.identifier.issn2515-8163
dc.identifier.scopus2-s2.0-85212976482
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1177/25158163241308795
dc.identifier.urihttps://hdl.handle.net/11616/108087
dc.identifier.volume7
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSAGE Publications Ltd
dc.relation.ispartofCephalalgia Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250329
dc.subjectantioxidant mechanism
dc.subjectnitric oxide
dc.subjectoxidative stress
dc.subjectpain
dc.subjectprimary headache
dc.titleAssociation between serum uric acid levels and chronic tension-type headache: A case–control study
dc.typeArticle

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