Preventive and early therapeutic effects of ?-Glucan on the bleomycin-induced lung fibrosis in rats

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dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridBilgic, Sedat/0000-0001-8410-2685
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidBİLGİÇ, Sedat/AEM-2044-2022
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidbilgiç, sedat/JVN-5459-2024
dc.contributor.authorIraz, M.
dc.contributor.authorBilgic, S.
dc.contributor.authorSamdanci, E.
dc.contributor.authorOzerol, E.
dc.contributor.authorTanbek, K.
dc.contributor.authorIraz, M.
dc.date.accessioned2024-08-04T20:41:12Z
dc.date.available2024-08-04T20:41:12Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: The beta-glucans are long-chain polymers of glucose, which comprise the fungal cell wall, stimulate cells of the innate immune system, enhance disturbed epithelization, and have antioxidant effects. Oxidative stress has been implicated in the pathogenesis of bleomycin-induced lung fibrosis and various antioxidant agents have been studied for prevention and treatment of the disease. In this experimental animal study, we assessed effects of beta-glucan, extracted from barley, on the bleomycin-induced lung fibrosis, and evaluated differences of starting before and after bleomycin instillation. MATERIALS AND METHODS: Male Spraque-Dawley rats were given a single dose of bleomycin in pulmonary fibrosis groups. First dose of beta-glucan and NAC was given three days before the bleomycin injection, and at one of the other group beta-glucan was started 12 hours after bleomycin and continued until 14th day. Fibrotic changes in lung were estimated by using Aschoft's criteria and measuring lung hydroxyproline content. RESULTS: Bleomycin induced severe pulmonary fibrosis with marked increase in hydroxyproline content of lung tissue and typical lung fibrosis, which was prevented by beta-glucan. Hydroxyproline level was significantly higher in bleomycin treated rats than the other groups, and its level was decreased in the therapeutic groups, especially in the beta-glucan post-bleomycin group fibrosis score, hydroxyproline and MDA levels returned to the control levels. On the other hand, reduced glutathione level elevated in the same group. CONCLUSIONS: The data suggest that beta-glucans have protective and early therapeutic effects against bleomycin-induced lung fibrosis in rats.en_US
dc.identifier.endpage1516en_US
dc.identifier.issn1128-3602
dc.identifier.issue8en_US
dc.identifier.pmid25967727en_US
dc.identifier.scopus2-s2.0-84942240281en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1505en_US
dc.identifier.urihttps://hdl.handle.net/11616/96981
dc.identifier.volume19en_US
dc.identifier.wosWOS:000354535200025en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbeta-glucanen_US
dc.subjectBleomycinen_US
dc.subjectLung fibrosisen_US
dc.subjectHydroxyprolineen_US
dc.subjectGlutathioneen_US
dc.subjectTherapeuticen_US
dc.titlePreventive and early therapeutic effects of ?-Glucan on the bleomycin-induced lung fibrosis in ratsen_US
dc.typeArticleen_US

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