Successful living donor liver transplantation of fulminant liver failure due to isoniazid prophylaxis
Küçük Resim Yok
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
BMJ Publishing Group
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Progressive liver failure is rarely seen in tuberculosis chemoprophylaxis with isoniazid. We present a case of a 32-year-old woman admitted to our clinic reporting abdominal pain, nausea and vomiting for 2 days. The initial diagnosis was fulminant toxic hepatitis due to isoniazid chemoprophylaxis, which was treated successfully with living donor transplantation. Tuberculosis continues to be a significant public health problem. Isoniazid-related hepatotoxicity is extremely rare in adults. The only treatment in cases of fulminant liver failure is orthotopic liver transplantation from a deceased or living donor. If a deceased donor is not available or the patient refuses this treatment, living donor transplantation is the only choice. Although rare, isoniazid used as protective therapy for pulmonary tuberculosis can lead to fulminant liver failure. When cadaveric liver transplantation is not available, living donor liver transplantation is vital. © 2015 CrossMark.
Açıklama
Anahtar Kelimeler
alanine aminotransferase, albumin, ammonia, aspartate aminotransferase, bilirubin, C reactive protein, creatinine, gamma glutamyltransferase, hemoglobin, isoniazid, methylprednisolone, nitrogen, tacrolimus, urea, isoniazid, tuberculostatic agent, abdominal pain, adult, arterial gas, Article, brain disease, case report, chemoprophylaxis, consciousness disorder, delirium, disease association, disease duration, disease exacerbation, drug blood level, drug withdrawal, female, fulminant hepatic failure, human, human tissue, immunosuppressive treatment, international normalized ratio, jaundice, length of stay, leukocyte count, liver graft rejection, liver toxicity, liver transplantation, living donor, multidetector computed tomography, nausea and vomiting, partial thromboplastin time, priority journal, prothrombin time, somnolence, thrombocyte count, tuberculosis, urea nitrogen blood level, chemically induced, Liver Failure, Acute, tuberculosis, Adult, Antitubercular Agents, Female, Humans, Isoniazid, Liver Failure, Acute, Liver Transplantation, Living Donors, Tuberculosis
Kaynak
BMJ Case Reports
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
2015
