Decreased endothelium-dependent vasodilatation in patients with migraine: a new aspect to vascular pathophysiology of migraine

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dc.authoridozcan, abdulcemal/0000-0002-6759-7556;
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.authorwosidaksoy, yüksel/ABH-1304-2021
dc.contributor.authorYetkin, E
dc.contributor.authorOzisik, H
dc.contributor.authorOzcan, C
dc.contributor.authorAksoy, Y
dc.contributor.authorTurhan, H
dc.date.accessioned2024-08-04T20:15:27Z
dc.date.available2024-08-04T20:15:27Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Migraine is a common neurovascular disorder characterized by attacks of severe headache, autonomic and neurological symptoms. We hypothesized that patients with migraine had abnormal endothelial function. The vascular theory of migraine assumes that the major pathophysiological events that initiate the migraine attack occur in the perivascular nerves of the major cerebral vessels. Accordingly, we aimed to measure endothelium-dependent vasoclilatation in migraineurs by means of flow-mediated dilatation, which reflects endothelium-dependent vasodilatation capacity. Materials and methods Forty-five patients who fulfilled the diagnostic criteria for migraine and 45 age and sex-matched healthy participants were enrolled in the study. Flow-mediated dilatation of the brachial artery was determined using a high-resolution B-mode ultrasonographic system. Flow-mediated vasodilatation was expressed as the change in post-stimulus diameter as a percentage of the baseline diameter. Results Mean ages of the patients were 33 +/- 10 years in migraineurs (range: 18-52 years, 36 female, 9 male) and 33 +/- 9 years in non-migraineurs (range: 17-50 years, 36 female and 9 male). Flow-mediated dilatation of patients with migraine is significantly lower than that of the controls (8.02 +/- 4.095% vs. 10.72 +/- 3.52%, respectively, P=0.001). Conclusion We have shown that migraineurs have decreased endothelium-dependent vasodilatation capacity compared with non-migraineurs. Migraine may be a local manifestation of systemic vascular vasomotion abnormalities.en_US
dc.identifier.doi10.1097/00019501-200602000-00005
dc.identifier.endpage33en_US
dc.identifier.issn0954-6928
dc.identifier.issn1473-5830
dc.identifier.issue1en_US
dc.identifier.pmid16374138en_US
dc.identifier.scopus2-s2.0-33646985392en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.1097/00019501-200602000-00005
dc.identifier.urihttps://hdl.handle.net/11616/94394
dc.identifier.volume17en_US
dc.identifier.wosWOS:000234323900005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCoronary Artery Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectendothelial functionen_US
dc.subjectflow-mediated dilatationen_US
dc.subjectmigraineen_US
dc.subjectnitrateen_US
dc.titleDecreased endothelium-dependent vasodilatation in patients with migraine: a new aspect to vascular pathophysiology of migraineen_US
dc.typeArticleen_US

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