Does Aluminum Cause Ototoxicity in Rats?

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dc.authoridBayindir, Tuba/0000-0003-4150-5016
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authorwosidBayindir, Tuba/ABG-9517-2020
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.contributor.authorSelimoglu, Erol
dc.contributor.authorBayindir, Tuba
dc.contributor.authorIraz, Mustafa
dc.contributor.authorGul, Mehmet
dc.contributor.authorDurgun, Yesim
dc.contributor.authorErdem, Tamer
dc.contributor.authorKalcioglu, Tayyar
dc.date.accessioned2024-08-04T20:32:50Z
dc.date.available2024-08-04T20:32:50Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Aluminum (Al) is a nonessential and toxic metal to which humans are frequently exposed. Except one study which revealed adverse effects of serum Al levels on the auditory functions in hemodialysis patients, there is not any other study on the effects of Al on auditory functions. Study design: Acute and chronic effects of Al on rat auditory system were investigated in that randomized controlled study. Methods: Forty five male Sprague-Dawley rats were included. Rats were divided into six groups according to the dose and route of Aluminum chloride (AlCl3): in groups A (n=7), B (n=9), and C (n=9), intraperitoneally (IP) AlCl3 was injected in doses of 1 mg/kg, 5mg/kg, and 80mg/kg, respectively; in control group (group K, n=6), saline was injected IP; in groups D (n=7) and E (n=7) oral AlCl3 was administered in doses of 5mg/kg, and 50mg/kg, respectively. OAE measurement was performed for four times in IP AlCl3 groups; before and on the 1st, 7th, and 14th days after aluminum administration. In oral group OAE measurement was performed before and on the 1st, 2nd, and 3rd months after aluminum administration. The distortion product otoacoustic emissions (DPOAEs) at 2f1-f2 were recorded and analyzed. Histological examination of the cochlea was performed. Results: DPOAE measurements of all groups before and after AlCl3 administrations were not statistically different. Histological examination revealed normal stria vascularis, spiral ganglion and organ of cord in all groups. Conclusion: Neither acute nor chronic administration of AlCl3 in aforementioned doses and routes caused neither clinical nor histological ototoxicity.en_US
dc.description.sponsorshipInonu Universityen_US
dc.description.sponsorshipThe authors are grateful to Inonu University for the funding of the research.en_US
dc.identifier.endpage224en_US
dc.identifier.issn1308-7649
dc.identifier.issn2148-3817
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-79957630817en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage215en_US
dc.identifier.urihttps://hdl.handle.net/11616/95336
dc.identifier.volume7en_US
dc.identifier.wosWOS:000208799600011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofJournal of International Advanced Otologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAluminumen_US
dc.subjectototoxicityen_US
dc.titleDoes Aluminum Cause Ototoxicity in Rats?en_US
dc.typeArticleen_US

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