The effect of formula type on the prognosis of allergic proctocolitis due to cow's milk allergy

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dc.contributor.authorCeliksoy, Mehmet Halil
dc.contributor.authorNaiboglu, Sezin
dc.contributor.authorTopal, Erdem
dc.contributor.authorKaradag, Sefika Ilknur Kokcu
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorBologur, Hamit
dc.date.accessioned2026-04-04T13:32:59Z
dc.date.available2026-04-04T13:32:59Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground: Food protein-induced allergic proctocolitis is a nonimmunoglobulin E-mediated, self-limited food allergy of the rectum and the colon. Cow's milk protein is the most common allergen responsible for the disease. Objective: This study aimed to investigate the roles of different types of formulas in building early tolerance to food protein-induced allergic proctocolitis in infants. Methods: The medical records of 45 pediatric patients diagnosed with proctocolitis due to cow's milk allergy between August 2021 and August 2023 and whose disease progression was followed in three tertiary care centers were reviewed retrospectively. Results: The study included 45 patients who were diagnosed with proctocolitis due to cow's milk allergy (24 males, 21 females; median age: 4 months). Among them, 24 patients were fed an amino acid-based formula, and 21 (46.7%) patients were fed an extensively hydrolyzed formula. The average age of acquisition of cow's milk tolerance was lower in the group fed with the amino acid-based formula than in the group fed with extensively hydrolyzed formula (P = 0.038). Furthermore, the group fed with amino acid-based formula had a shorter tolerance period than the group fed with the extensively hydrolyzed formula group (P = 0.044). Conclusion: Compared to an extensively hydrolyzed formula, an amino acid-based formula led to the early development of tolerance in children with allergic proctocolitis induced by cow's milk. (c) 2025 Codon Publications. Published by Codon Publications.
dc.identifier.doi10.15586/aei.v53i1.1240
dc.identifier.endpage130
dc.identifier.issn0301-0546
dc.identifier.issn1578-1267
dc.identifier.issue1
dc.identifier.pmid39786885
dc.identifier.scopus2-s2.0-85214866293
dc.identifier.scopusqualityQ2
dc.identifier.startpage126
dc.identifier.urihttps://doi.org/10.15586/aei.v53i1.1240
dc.identifier.urihttps://hdl.handle.net/11616/108850
dc.identifier.volume53
dc.identifier.wosWOS:001389953900017
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCodon Publications
dc.relation.ispartofAllergologia Et Immunopathologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectallergic proctocolitis
dc.subjectcow's milk allergy
dc.subjectfood allergy
dc.subjecttolerance
dc.titleThe effect of formula type on the prognosis of allergic proctocolitis due to cow's milk allergy
dc.typeArticle

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