Green Extraction Enhances Antioxidant and Cytotoxic Properties of Pomegranate By-Products Against Human Cancer Cell Lines

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dc.contributor.authorAydin, Merve
dc.contributor.authorAkbulut, Sumeyye
dc.contributor.authorKeskin, Tuba
dc.contributor.authorTontul, Ismail
dc.contributor.authorTurker, Selman
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2026-04-04T13:37:26Z
dc.date.available2026-04-04T13:37:26Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractThe aim of this study was to determine the anticancer effects of extract obtained from pomegranate by-products by green extraction (ultrafiltration and enzymatic extraction) (GE) on prostate (LNCaP), ovarian (A2780), breast (MCF-7), and colon (Caco-2) cancer cell lines compared to the traditional extraction (TE) and pomegranate juice (PJ). The GE sample demonstrated the highest total or individual phenolic content, and antioxidant activity. The major phenolics in all samples were determined to be ellagic acid, punicalagin A and punicalagin B. The 50% and 100% doses of the PJ exhibited a significant reduction in the viability of all cancer cells except LNCaP cells (only 100%) (p < 0.05). The TE sample showed a significant decrease in the viability of all cancer cells except the MCF-7 cell line (at all doses) at doses other than 1 M (p < 0.05). The GE sample caused a significant decrease in all cancer cells at all doses (1, 5, 25, 50, 100 and 150 M) (p < 0.05). Consequently, the GE sample applied with the green method was effective at all doses in reducing the viability of cancer cells.
dc.identifier.doi10.1007/s11130-025-01404-w
dc.identifier.issn0921-9668
dc.identifier.issn1573-9104
dc.identifier.issue4
dc.identifier.orcid0000-0002-9212-4021
dc.identifier.orcid0000-0002-0626-9911
dc.identifier.pmid41026291
dc.identifier.scopus2-s2.0-105017566771
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s11130-025-01404-w
dc.identifier.urihttps://hdl.handle.net/11616/109825
dc.identifier.volume80
dc.identifier.wosWOS:001585893300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPlant Foods For Human Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectCancer
dc.subjectAntiproliferative
dc.subjectPomegranate by-product
dc.subjectExtract
dc.subjectGreen extraction
dc.titleGreen Extraction Enhances Antioxidant and Cytotoxic Properties of Pomegranate By-Products Against Human Cancer Cell Lines
dc.typeArticle

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