Comparison of the Effects of Low-Level Laser Therapy and Ozone Therapy on Bone Healing

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridYolcu, Ümit/0000-0001-7312-2867;
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidAcar, Ahmet Hüseyin/KWT-7138-2024
dc.authorwosidYolcu, Ümit/ABH-6916-2020
dc.authorwosidalan, hilal/ABH-9301-2020
dc.contributor.authorAlan, Hilal
dc.contributor.authorVardi, Nigar
dc.contributor.authorOzgur, Cem
dc.contributor.authorHuseyin, Ahmet
dc.contributor.authorYolcu, Umit
dc.contributor.authorDogan, Derya Ozdemir
dc.date.accessioned2024-08-04T20:41:45Z
dc.date.available2024-08-04T20:41:45Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study aims to compare the effect of low-level laser therapy (LLLT) and ozone therapy on the bone healing. Thirty-six adult male Wistar albino rats were used for this study. Monocortical defects were shaped in right femur of all rats. Defects were filled with nano-hydroxyapatite graft. The animals were divided into 3 groups and each group was than divided into 2 subgroups. Then, LLLT with a diode laser was applied to the first group (G1), ozone therapy was applied to the second group (G2), and no treatment was applied to the third group as a control group (G3). Animals were sacrificed after 4th and 8th weeks and the sections were examined to evaluate the density of the inflammation, the formation of connective tissue, the osteogenic potential, and osteocalcin activity. As a result, there were no significant differences among the groups of 4 weeks in terms of new bone formation. In the immunohistochemical assessment, the number of osteocalcin-positive cells was higher in the laser group compared to the other group of 4 weeks; this difference was statistically significant in the LLLT and ozone groups (P < 0.05). Histomorphometric assessment showed that the new bone areas were higher in the LLLT and ozone groups; furthermore, there was a statistically significant difference in the LLLT in comparison with the control group at 8th week (P < 0.05). At the same time immunohistochemical assessment showed that osteocalcin-positive cells were considerably higher in G2 than G1 at 8th week (P < 0.05). The findings of this study may be the result of differences in the number of treatment sessions. Further studies are therefore needed to determine the optimal treatment modality.en_US
dc.description.sponsorshipScientific Research Council of Inonu University [2012-156]en_US
dc.description.sponsorshipThis project was funded by the Scientific Research Council of Inonu University (2012-156).en_US
dc.identifier.doi10.1097/SCS.0000000000001871
dc.identifier.endpageE400en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue5en_US
dc.identifier.pmid26167994en_US
dc.identifier.scopus2-s2.0-84965150687en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE396en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000001871
dc.identifier.urihttps://hdl.handle.net/11616/97306
dc.identifier.volume26en_US
dc.identifier.wosWOS:000369611000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone healingen_US
dc.subjectlow-level laser therapyen_US
dc.subjectozoneen_US
dc.subjectraten_US
dc.titleComparison of the Effects of Low-Level Laser Therapy and Ozone Therapy on Bone Healingen_US
dc.typeArticleen_US

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