Acute Normovolemic Hemodilution in Coronary Artery Bypass Surgery: Effects on Inflammatory Response
Küçük Resim Yok
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Acute normovolemic hemodilution is the removal of the blood from patients before or shortly after induction of anesthesia, and simultaneous replacement with acellular fluid, that is crystalloid or colloid and retransfusion of removed blood if needed. In this study we aimed to evaluate the effects of acute normovolemic hemodilution on and enflammatory response in patients undergoing coronary artery bypass surgery. After Ethics Committee approval 40 patients undergoing coronary artery bypass surgery were divided into two groups randomly. After induction of anesthesia, one or two units of blood were drawn from the Group I (n=20) until the hematocrit values became lesser than < 35%. At the same time, volume replacement was achieved with same amount of colloid infusion from peripheral vein. Any additional procedure was not done to the control group (Group II, n=20). Alanine transaminase, aspartate transaminase, lactate dehydrogenase, creatine kinase MB, creatine phosphokinase, ?-glutamyl transferase, complement 3a, complement 4a, ferritin, transferrin, nitric oxide, C-reactive protein and haptoglobulin levels were measured before induction, after operation, postoperative 6th and 24th hours. The amount of transfused allogenic blood was lower in Group I compared to group II (p<0.05). It was detected that complement system was not induced in two groups; lactate dehydrogenase, creatine kinase MB and nitric oxide levels were higher in Group II at postoperative 6 th, ferritin level was higher in group I at postoperative 24 th hours statistically (p<0.05). It was concluded that the effect of acute normovolemic hemodilution regarding to complement system was not different from control group and lower levels in lactate dehydrogenase, creatine kinase MB and nitric oxide can show that organ functions can be better prevented with acute normovolemic hemodilution.
Açıklama
Anahtar Kelimeler
Hemodilution, Systemic inflammatory response
Kaynak
Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
31
Sayı
6
