Effect of Inflammatory Markers on the Pathologic Complete Response in the Neoadjuvan Treatment of HER-2 Positive Local Advanced Breast Cancer

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dc.contributor.authorGülmez, Ahmet
dc.contributor.authorHakan, Harputluoglu
dc.date.accessioned2024-08-04T19:51:22Z
dc.date.available2024-08-04T19:51:22Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: This study aimed to retrospectively investigate the rate of pathological complete response (pCR) and markers predicting this response for trastuzumab and pertuzumab-containing regimens compared to trastuzumabcontaining regimens for stage II to III HER-2 positive breast cancer (BC). Methods: In this study, we retrospectively analyzed the data of patients with Her-2 positive advanced BC who were treated with trastuzumab or trastuzumab and pertuzumab in addition to neoadjuvant chemotherapy. Patients were classified according to their pre-treatment clinical stages, hormone receptor status, Her-2 immuno-histochemical score, ki-67 index, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and prognostic nutritional index (PNI) ratio. Results: For NLR, it was 1.9±0.85 in patients with pCR and 2.4±0.83 in patients without pCR. For PLR it was 112±53.3 and 129.4±36.2, respectively. For PNI, it was 51.6±5.8 and 48.1±5.9. Low NLR and PLR as well as high PNI were significantly associated with pCR. In addition, the pCR of patients with hormone receptor negativity and dual Her-2 blockade was statistically significant. Conclusion: This is the first study in the literature to show that prognostic scores such as NLR, PLR, and PNI have statistically significant benefits on pCR in patients treated with the neoadjuvant dual blockade.en_US
dc.identifier.doi10.14744/ejmi.2022.65683
dc.identifier.endpage423en_US
dc.identifier.issn2602-3164
dc.identifier.issue4en_US
dc.identifier.startpage417en_US
dc.identifier.trdizinid1133716en_US
dc.identifier.urihttps://doi.org/10.14744/ejmi.2022.65683
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1133716
dc.identifier.urihttps://hdl.handle.net/11616/88920
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofEurasian Journal of Medical Investigationen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffect of Inflammatory Markers on the Pathologic Complete Response in the Neoadjuvan Treatment of HER-2 Positive Local Advanced Breast Canceren_US
dc.typeArticleen_US

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