Exploiting ionisable nature of PEtOx-co-PEI to prepare pH sensitive, doxorubicin-loaded micelles

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dc.authoridOzkose, Umut Ugur/0000-0003-4807-6322
dc.authoridOzturk, Naile/0000-0002-7617-8433
dc.authoridGulyuz, Sevgi/0000-0002-2576-3085
dc.authoridYILMAZ, ÖZGÜR/0000-0003-3892-2775
dc.authoridtasdelen, mehmet atilla/0000-0002-7012-7029
dc.authoridKARA, ASLI/0000-0002-0347-0222
dc.authorwosidOzkose, Umut Ugur/AAS-3585-2021
dc.authorwosidKara, Asli/ABB-8903-2021
dc.authorwosidOzturk, Naile/F-3650-2017
dc.authorwosidGulyuz, Sevgi/ABI-5064-2020
dc.authorwosidYILMAZ, ÖZGÜR/AAG-2472-2021
dc.authorwosidtasdelen, mehmet atilla/B-8338-2008
dc.contributor.authorOzturk, Naile
dc.contributor.authorKara, Asli
dc.contributor.authorGulyuz, Sevgi
dc.contributor.authorOzkose, Umut Ugur
dc.contributor.authorTasdelen, Mehmet Atilla
dc.contributor.authorBozkir, Asuman
dc.contributor.authorYilmaz, Ozgur
dc.date.accessioned2024-08-04T20:48:44Z
dc.date.available2024-08-04T20:48:44Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAims This study was conducted to evaluate block copolymers containing two different poly(ethyleneimine) (PEI) amounts, as new pH-sensitive micellar delivery systems for doxorubicin. Methods Micelles were prepared with block copolymers consisting of poly(2-ethyl-2-oxazoline)-co-poly(ethyleneimine) (PEtOx-co-PEI) and poly(epsilon-caprolactone) (PCL) as hydrophilic and hydrophobic blocks, respectively. Doxorubicin loading, micelle size, pH-dependent drug release, and in vitro cytotoxicity on MCF-7 cells were investigated. Results The average size of drug-loaded micelles was under 100 nm and drug loading was between 10.7% and 48.3% (w/w). pH-sensitive drug release was more pronounced (84.7% and 68.9% (w/w) of drug was released at pH 5.0 and pH 7.4, respectively) for the micelles of the copolymer with the lowest PEI amount. The cell viability of doxorubicin-loaded micelles which were prepared by the copolymer with the lowest PEI amount was 28-33% at 72 h. Conclusions PEtOx-co-PEI-b-PCL micelles of this copolymer were found to be stable and effective pH-sensitive nano-sized carriers for doxorubicin delivery.en_US
dc.description.sponsorshipTUBITAK [213M728]en_US
dc.description.sponsorshipThis study was supported by TUBITAK Grant 213M728.en_US
dc.identifier.doi10.1080/02652048.2020.1792566
dc.identifier.endpage480en_US
dc.identifier.issn0265-2048
dc.identifier.issn1464-5246
dc.identifier.issue7en_US
dc.identifier.pmid32627670en_US
dc.identifier.scopus2-s2.0-85087898563en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage467en_US
dc.identifier.urihttps://doi.org/10.1080/02652048.2020.1792566
dc.identifier.urihttps://hdl.handle.net/11616/99414
dc.identifier.volume37en_US
dc.identifier.wosWOS:000547724300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Microencapsulationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectpoly(2-ethyl-2-oxazoline)en_US
dc.subjectpH-sensitive releaseen_US
dc.subjectpoly(ethyleneimine)en_US
dc.subjectmicellesen_US
dc.subjectblock copolymersen_US
dc.titleExploiting ionisable nature of PEtOx-co-PEI to prepare pH sensitive, doxorubicin-loaded micellesen_US
dc.typeArticleen_US

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