Synthesis, Characterization, and Anticancer Activity of New Benzofuran Substituted Chalcones

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dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.contributor.authorCoskun, Demet
dc.contributor.authorTekin, Suat
dc.contributor.authorSandal, Suleyman
dc.contributor.authorCoskun, Andmehmet Fatih
dc.date.accessioned2024-08-04T20:42:35Z
dc.date.available2024-08-04T20:42:35Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBenzofuran derivatives are of great interest in medicinal chemistry and have drawn considerable attention due to their diverse pharmacological profiles including anticancer activity. Similarly, chalcones, which are common substructures of numerous natural products belonging to the flavonoid class, feature strong anticancer properties. A novel series of chalcones, 3-aryl-1-(5-bromo-1-benzofuran-2-yl)-2-propanones propenones (3a-f), were designed, synthesized, and characterized. In vitro antitumor activities of the newly synthesized (3a-f) and previously synthesized (3g-j) chalcone compounds were determined by using human breast (MCF-7) and prostate (PC-3) cancer cell lines. Antitumor properties of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell viability assay for the tested chalcone compounds was performed and the log IC50 values of the compounds were calculated after 24-hour treatment. Our results indicate that the tested chalcone compounds show antitumor activity against MCF-7 and PC-3 cell lines (p < 0.05).en_US
dc.description.sponsorshipFirat Universityen_US
dc.description.sponsorshipThe authors thank Firat University for financial support of this work.en_US
dc.identifier.doi10.1155/2016/7678486
dc.identifier.issn2090-9063
dc.identifier.issn2090-9071
dc.identifier.scopus2-s2.0-84982798852en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1155/2016/7678486
dc.identifier.urihttps://hdl.handle.net/11616/97467
dc.identifier.volume2016en_US
dc.identifier.wosWOS:000381146000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofJournal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiological Evaluationen_US
dc.subjectIn-Vitroen_US
dc.subjectDerivativesen_US
dc.subjectAntibacterialen_US
dc.subjectResistanceen_US
dc.subjectInhibitorsen_US
dc.subjectDesignen_US
dc.subjectSeriesen_US
dc.titleSynthesis, Characterization, and Anticancer Activity of New Benzofuran Substituted Chalconesen_US
dc.typeArticleen_US

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