Investigation of the Relationship of Nesfatin-1, Adropin Levels and Claudin-2, Renalase Immunoreactivity with Kidney Function in an Experimental Hypertension Model

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dc.contributor.authorAydin, Muhammed Ali
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorTastekin, Ebru
dc.contributor.authorFirat, Nihayet
dc.contributor.authorYavuz, Ozlem Yalcinkaya
dc.date.accessioned2024-08-04T20:55:11Z
dc.date.available2024-08-04T20:55:11Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Hypertension is one of the cardiovascular diseases that causes the most mortality, and 95% of the causes are unknown. The aim of the study was to examine the possible correlation of nesfatin-1 levels, adropin levels, claudin-2 immunoreactivity (claudin-2 expression in the renal proximal tubule), and renalase immunoreactivity (renalase expression in the renal proximal tubule) with arterial blood pressure, kidney function, and kidney damage. Methods: Adult male Sprague-Dawley rats were divided into control and hypertension groups (8 per group). Angiotensin II vehicle was given to the control group and angiotensin II (0.7 mg/kg/day) to the hypertension group, both via an osmotic mini pump for 7 days. The animals blood pressures were measured by tail cuff plethysmography on days 1, 3, 5, and 7. On day 7, 24-hour urine, blood, and tissues were collected from the rats. Results: In the hypertension group compared with the control group, there was an increase in systolic blood pressure levels after day 1. While claudin-2 immunoreactivity was reduced in the kidneys, renalase immunoreactivity was increased. There was a decrease in creatinine clearance and an increase in fractional potassium excretion (P < .05). Conclusion: Our results showed that claudin-2 and renalase are associated with renal glomerular and tubular dysfunction and may play discrete roles in the pathogenesis of hypertension. We believe that these potential roles warrant further investigation.en_US
dc.description.sponsorshipTrakya University TUBAP project [2017/116]en_US
dc.description.sponsorshipAcknowledgments This study was supported by the Trakya University TUBAP project, numbered 2017/116.en_US
dc.identifier.endpage45en_US
dc.identifier.issn0738-0658
dc.identifier.issn2373-6011
dc.identifier.issue1en_US
dc.identifier.pmid38512760en_US
dc.identifier.scopus2-s2.0-85188579004en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://hdl.handle.net/11616/101893
dc.identifier.volume43en_US
dc.identifier.wosWOS:001245944600006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Puerto Rico Medical Sciences Campusen_US
dc.relation.ispartofPuerto Rico Health Sciences Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypertensionen_US
dc.subjectClaudin-2en_US
dc.subjectRenalaseen_US
dc.subjectNesfatin-1en_US
dc.subjectAdropinen_US
dc.titleInvestigation of the Relationship of Nesfatin-1, Adropin Levels and Claudin-2, Renalase Immunoreactivity with Kidney Function in an Experimental Hypertension Modelen_US
dc.typeArticleen_US

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