Effects of caffeic acid phenethyl ester on thioacetamide-induced hepatic encephalopathy in rats

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dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.contributor.authorFadillioglu, Ersin
dc.contributor.authorGursul, Cebrail
dc.contributor.authorIraz, Mustafa
dc.date.accessioned2024-08-04T20:32:39Z
dc.date.available2024-08-04T20:32:39Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHepatic encephalopathy (HE) is a major neurological complication secondary to severe liver failure. The aim of the present study was to examine the possible neuroprotective effects of caffeic acid phenethyl ester (CAPE) with or without laxative treatment against thioacetamide-induced HE by investigating behavioral and motor activities in rats as well as blood ammonia level and oxidant-antioxidant parameters of cortex, brain stem and cerebellum. After induction of HE by thioacetamide, the rats were treated with lactulose, CAPE (CAPE treatment was started one day before the first dose of thioacetamide) or CAPE plus lactulose. The behavioral and motor scales were measured at the 54th hour after the first thioacetamide injection, the blood samples and brains were taken under anesthesia at the 60th hour for biochemical analysis. The survival rates were 37.5% in HE group, 70% in HE + lactulose group, 80% in HE + CAPE group, and 100% in HE + CAPE + lactulose group. Increased ammonia, ALT and AST levels in blood along with impaired sensory-motor behavior tests were reversed to proximate control values in CAPE + lactulose treated group. There were increased lipid peroxidation and protein oxidation and decreased antioxidant enzyme activities in almost all brain parts of HE group. CAPE or lactulose treatment alone ameliorated those oxidant and antioxidant parameters; however, CAPE treatment together with lactulose reversed them to almost control level. In conclusion, thioacetamide-induced HE injury in rats was reversed almost fully by CAPE and laxative combination. There was no death in CAPE and laxative treated group animals and it may be due to the direct neuroprotective effect of CAPE together with the prevention of the body from ammonia production. (C) 2010 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipScientific Research Institution of Inonu University [2005/75]en_US
dc.description.sponsorshipThis study was supported by a grant from the Scientific Research Institution of Inonu University (Project No: 2005/75). This study was partly presented in '32thNational Physiological Sciences Congress'.en_US
dc.identifier.doi10.1016/j.pnpbp.2010.07.034
dc.identifier.endpage1445en_US
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.issue8en_US
dc.identifier.pmid20708059en_US
dc.identifier.scopus2-s2.0-78649506730en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1440en_US
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2010.07.034
dc.identifier.urihttps://hdl.handle.net/11616/95196
dc.identifier.volume34en_US
dc.identifier.wosWOS:000285948800012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectCAPEen_US
dc.subjectHepatic encephalopathyen_US
dc.subjectOxidantsen_US
dc.subjectThioacetamideen_US
dc.titleEffects of caffeic acid phenethyl ester on thioacetamide-induced hepatic encephalopathy in ratsen_US
dc.typeReview Articleen_US

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