Association Between Age-Related Cataract and Knee Osteoarthritis: a Comparative and Correlational Study Focusing on Disease Severity

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dc.contributor.authorDemir, Ulku
dc.contributor.authorOcal, Halit
dc.contributor.authorSenkoy, Emre
dc.date.accessioned2026-04-04T13:19:13Z
dc.date.available2026-04-04T13:19:13Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractIntroduction: There are several common features between age-related cataract and knee osteoarthritis. Both disorders are associated with serum immunoglobulin E levels, connective tissue growth factor, and oxidative stress. Musculoskeletal disorders have been ide ntified as the most common comorbidities in patients with age-related cataract, with knee osteoarthritis being the most frequent. Therefore, the authors aimed to further investigate this association, considering the severity of these disorders. Materials and Methods: In this study, data from 350 knee joints and 350 eyes were analyzed. The severity of knee osteoarthritis was assessed radiographically using the Kellgren-Lawrence (KL) grading system. The severity of cataracts was evaluated based on the degree of opacification, using the Lens Opacities Classification System III. Results: Cataract grades were significantly lower in KL grade 0 compared to other grades for cortical cataract and posterior subcapsular cataract. Additionally, cataract grades were significantly lower in KL grade 1 compared to grades 3 and 4 for posterior subcapsular cataract. There were significant positive correlations between knee osteoarthritis grades and the grades of nuclear cataract, cortical cataract, and posterior subcapsular cataract Conclusions: There is a significant relationship between age-related cataracts and knee osteoarthritis in terms of disease severity. Beyond their association with aging, these two conditions may share common pathophysiological features. This study may provide new insights into the mechanisms underlying age-related cataracts and knee osteoarthritis. © 2026, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
dc.identifier.doi10.5505/vmj.2026.32559
dc.identifier.endpage44
dc.identifier.issn1300-2694
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105029160940
dc.identifier.scopusqualityN/A
dc.identifier.startpage40
dc.identifier.urihttps://doi.org/10.5505/vmj.2026.32559
dc.identifier.urihttps://hdl.handle.net/11616/108235
dc.identifier.volume33
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherYuzuncu Yil Universitesi Tip Fakultesi
dc.relation.ispartofVan Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250329
dc.subjectaging
dc.subjectCataract
dc.subjectknee joints
dc.subjectknee osteoarthritis
dc.subjectlens opacity
dc.titleAssociation Between Age-Related Cataract and Knee Osteoarthritis: a Comparative and Correlational Study Focusing on Disease Severity
dc.typeArticle

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