Dexmedetomidine ameliorates TNBS-induced colitis by inducing immunomodulator effect

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dc.authoridErdogan Kayhan, Gulay/0000-0002-2635-9295
dc.authoridGedik, Ender/0000-0002-7175-207X
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authoridKAYHAN, BASAK/0000-0003-3508-2563
dc.authoridOZGUL, Ulku/0000-0003-3738-1751
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authorwosidErdogan Kayhan, Gulay/JVZ-0037-2024
dc.authorwosidGedik, Ender/ABI-2971-2020
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.authorwosidDurmuş, Mahmut/AAG-3377-2019
dc.authorwosidASLAN, Elçin Latife/A-3923-2017
dc.authorwosidKAYHAN, BASAK/ABH-9314-2020
dc.authorwosidOZGUL, Ulku/ABI-6823-2020
dc.contributor.authorKayhan, Gulay Erdogan
dc.contributor.authorGul, Mehmet
dc.contributor.authorKayhan, Basak
dc.contributor.authorGedik, Ender
dc.contributor.authorOzgul, Ulku
dc.contributor.authorKurtoglu, Elcin Latife
dc.contributor.authorDurmus, Mahmut
dc.date.accessioned2024-08-04T20:37:43Z
dc.date.available2024-08-04T20:37:43Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Since sedatives are often administered to immune-compromised and critically ill patients, our understanding of immunomodulation by sedation will be critical. Dexmedetomidine, a selective alpha(2)-adrenergic receptor agonist, is often used for sedation and analgesia especially in intensive care units. There are conflicting and little data concerning both the effect and the mechanism of dexmedetomidine on immune response. In our study, we aimed to investigate the effect of dexmedetomidine on immune system at two different doses (5 mu g.kg(-1) and 30 mu g.kg(-1)) during inflammatory bowel disease by using an experimental model, which resembles both systemic and local inflammation. Methods: The effect of dexmedetomidine on the course of inflammatory bowel disease was investigated by measuring macroscopic and microscopic parameters. We investigated pro-inflammatory Th1, Th2, and Th17 cytokine levels in serum samples to analyze systemic immune response. Following this, local immune response was investigated by measuring cytokine levels in the presence of dexmedetomidine in spleen cell culture. Results: Dexmedetomidine administration led to amelioration of all disease associated pathological manifestations. According to our in vitro and in vivo results, dexmedetomidine shows anti-inflammatory effect by increasing IL-4 and IL-10 levels responsible from anti-inflammatory response via Th2 pathway. Moreover, we showed for the first time in the study that dexmedetomidine administration reduces IL-23, which is responsible from initiation of inflammatory response via Th17 pathway. Conclusions: Dexmedetomidine can have beneficial effect on preoperative or postoperative inflammatory bowel disease patients in intensive care units by down-regulating inflammatory immune response not only in systemic circulation but also in tissue-specific manner. (c) 2013 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) in short-term R&D Funding Programme [110S243]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) in short-term R&D Funding Programme (110S243).en_US
dc.identifier.doi10.1016/j.jss.2013.03.028
dc.identifier.endpage741en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue2en_US
dc.identifier.pmid23582761en_US
dc.identifier.scopus2-s2.0-84880295457en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage733en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2013.03.028
dc.identifier.urihttps://hdl.handle.net/11616/96140
dc.identifier.volume183en_US
dc.identifier.wosWOS:000321737300039en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInflammatory bowel diseasesen_US
dc.subjectDexmedetomidineen_US
dc.subjectImmune responseen_US
dc.subjectCytokinesen_US
dc.titleDexmedetomidine ameliorates TNBS-induced colitis by inducing immunomodulator effecten_US
dc.typeArticleen_US

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