Predictive value of inflammatory and hematological data in diabetic and non-diabetic retinopathy

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dc.contributor.authorAtli, H.
dc.contributor.authorOnalan, E.
dc.contributor.authorYakar, B.
dc.contributor.authorDuzenci, D.
dc.contributor.authorDonder, E.
dc.date.accessioned2024-08-04T20:51:37Z
dc.date.available2024-08-04T20:51:37Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: The current study aimed at investigating the predictive role of inflammatory, hematological and biochemical parameters in diabetic and non-diabetic retinopathy. MATERIALS AND METHODS: The cross-sectional study was conducted between June 2019 and September 2020. We included patients with diabetic retinopathy (proliferative DR=14, non-proliferative DR=16), patients with non-diabetic retinopathy (n=30), patients with Type 2 Diabetes Mellitus (T2DM) without retinopathy (n=30) and control group (n=30). Demographic, hematological, and biochemical parameters of the participants were examined. RESULTS: Participants' age and duration of diabetes mellitus were higher in proliferative and non-proliferative DR groups than patients with T2DM without retinopathy (p<0.001). There were significantly difference in terms of BMI (p<0.001), HbA1c (p<0.001), glucose (p<0.001), LDL (p<0.001), AST (p=0.001), hemoglobin (p<0.001), urea (p<0.001), creatinine (p<0.001), lymphocyte (p=0.001), and neutrophil (p=0.002) levels between groups. IL-6 levels were higher in proliferative DR, non-proliferative DR, and non-diabetic retinopathy groups than the control group. TNF-alpha levels were higher in proliferative DR and non-diabetic retinopathy groups than the control group. The NLR and PLR median values were significantly higher in the proliferative DR group than in other groups (p<0.001). CONCLUSIONS: The current study showed that IL-6 and TNF-alpha levels are elevated in diabetic and non-diabetic retinopathy. In addition, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) median levels are higher in proliferative diabetic retinopathy than other groups. These findings support the inflammatory process may be accelerating the development of retinopathy.en_US
dc.identifier.endpage83en_US
dc.identifier.issn1128-3602
dc.identifier.issue1en_US
dc.identifier.pmid35049022en_US
dc.identifier.scopus2-s2.0-85123668934en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage76en_US
dc.identifier.urihttps://hdl.handle.net/11616/100446
dc.identifier.volume26en_US
dc.identifier.wosWOS:000746376400012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectRetinopathyen_US
dc.subjectNeutrophil/lymphocyte ratioen_US
dc.subjectPlateleten_US
dc.subjectlymphocyte ratioen_US
dc.titlePredictive value of inflammatory and hematological data in diabetic and non-diabetic retinopathyen_US
dc.typeArticleen_US

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