Epidemiology and Outcomes of Neonatal Meningitis Results of the Turkish Neo-Meningitis Nationwide Study

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dc.authorscopusid53364209100
dc.authorscopusid36007069800
dc.authorscopusid36994455700
dc.authorscopusid57226059050
dc.authorscopusid9639537600
dc.authorscopusid58764004500
dc.authorscopusid23490513100
dc.contributor.authorOncel M.Y.
dc.contributor.authorCizmeci M.N.
dc.contributor.authorKaradag-Oncel E.
dc.contributor.authorElvan-Tuz A.
dc.contributor.authorCanpolat F.E.
dc.contributor.authorAkin M.A.
dc.contributor.authorUslu S.
dc.date.accessioned2024-08-04T19:59:33Z
dc.date.available2024-08-04T19:59:33Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To investigate the incidence and etiology of neonatal meningitis and to assess the associated risk factors, complications and outcomes in a nationwide multicenter retrospective descriptive study. Method: Twenty-seven centers from 7 geographical regions participated in the study. Newborns with a positive cerebrospinal fluid culture and/or cerebrospinal fluid polymerase chain reaction were included in the study. Demographic characteristics, clinical, laboratory and neuroimaging findings and mortality characteristics were analyzed. Results: A total of 634 confirmed cases of neonatal meningitis were included in the final analysis. The incidence was 2.51 per 1000 intensive care unit hospitalizations and mortality was observed in 149 (23.5%). Gram-positive bacteria were the predominant pathogens (54.5%), with coagulase-negative Staphylococci accounting for 45.3% of the cases, followed by Gram-negative organisms (37.3%). Viral and fungal organisms were isolated in 3.2% and 1.7% of the infants, respectively. Gram-negative culture growth was more common in infants who died (51% vs. 34.6%; P < 0.001). In the multivariable model, the odds of mortality was higher in those with respiratory distress requiring invasive ventilatory support [odds ratio (OR): 10.3; 95% confidence interval (CI): 4.9–21.7; P < 0.01], hypotension requiring inotropes (OR: 4.4; 95% CI: 2.7–7.1; P < 0.001), low birth weight status (OR: 2.5; 95% CI: 1.4–4.6; P = 0.002), lack of exposure to antenatal steroids (OR: 2.4; 95% CI: 1.3–4.4; P = 0.005) and the presence of concomitant sepsis (OR: 1.9; 95% CI: 1.1–3.2; P = 0.017). Conclusions: In this nationwide study, neonatal meningitis was found to be associated with high mortality. Coagulase-negative Staphylococci was the most common causative microorganism followed by Gram-negative bacteria. Severe clinical presentation with invasive mechanical ventilation and inotrope requirement, as well as concomitant sepsis, low birth weight status and lack of exposure to antenatal steroids, were found to be independent risk factors for mortality. © 2024 Wolters Kluwer Health, Inc. All rights reserved.en_US
dc.identifier.doi10.1097/INF.0000000000004197
dc.identifier.endpage370en_US
dc.identifier.issn0891-3668
dc.identifier.issue4en_US
dc.identifier.pmid38134373en_US
dc.identifier.scopus2-s2.0-85187208247en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage365en_US
dc.identifier.urihttps://doi.org/10.1097/INF.0000000000004197
dc.identifier.urihttps://hdl.handle.net/11616/90716
dc.identifier.volume43en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofPediatric Infectious Disease Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectepidemiologyen_US
dc.subjectmeningitisen_US
dc.subjectmortalityen_US
dc.subjectnewbornen_US
dc.subjectoutcomesen_US
dc.titleEpidemiology and Outcomes of Neonatal Meningitis Results of the Turkish Neo-Meningitis Nationwide Studyen_US
dc.typeArticleen_US

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