Quercetin dose affects the fate of hepatic ischemia and reperfusion injury in rats: An experimental research

dc.contributor.authorUylas, Mustafa Ufuk
dc.date.accessioned2019-07-25T06:06:41Z
dc.date.available2019-07-25T06:06:41Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: Quercetin found in fruits and vegetables has an antioxidative effect. We aimed to investigate the protective effects of quercetin according to different doses on hepatic and ischemia-reperfusion (I/R) injury. METHODS: Fifty mature male Sprague-Dawley rats were randomly divided into five groups (n = 10 for each). All the animal groups underwent laparotomy. Group 1 rats served as a sham-operated group. Groups 2-5 underwent 1 h hepatic ischemia and were followed by 2 h reperfusion. Group 3-5 animals received an additional intraperitoneal dose of 25, 50 or 100 mg/kg quercetin respectively before I/R operation. Blood samples were collected for determining serum aspartate transaminase (AST), alanine transaminase (ALT) and malondialdehyde (MDA) levels. Also, liver tissue samples were taken for measuring of liver MDA concentration and for histopathology assessment. RESULTS: The highest levels of biochemical parameters were observed in group 2. In quercetin-treated groups, serum AST, ALT, MDA levels, and tissue MDA concentration were decreased as inversely with increasing quercetin dose. Microscopic evaluation revealed that most conspicuous histological improvement was observed in 50 mg/kg quercetin co-treated rats. 25 and 100 mg/kg quercetin co-treatment could not protect completely against hepatic I/R injury. CONCLUSION: Quercetin can be effective in preventing of hepatic I/R injury when the correct dose was used.en_US
dc.identifier.citationUylas, MU. (2018). Quercetin dose affects the fate of hepatic ischemia and reperfusion injury in rats: An experimental research. Cilt:53, 117-121 ss.en_US
dc.identifier.doi10.1016/j.ijsu.2018.03.043en_US
dc.identifier.endpage121en_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://hdl.handle.net/11616/12922
dc.identifier.volume53en_US
dc.language.isoenen_US
dc.publisherElsevıer scıence bv, po box 211, 1000 ae amsterdam, netherlandsen_US
dc.relation.ispartofInternatıonal journal of surgeryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRenal Ischemıa/Reperfusıon Injuryen_US
dc.subjectInduced Oxıdatıve Stressen_US
dc.subjectReactıve Oxygenen_US
dc.subjectFlavonoıd Quercetınen_US
dc.subjectLıveren_US
dc.subjectPretreatmenten_US
dc.subjectHepatocytesen_US
dc.subjectMechanısmsen_US
dc.subjectPreventıonen_US
dc.subjectProtectıonen_US
dc.titleQuercetin dose affects the fate of hepatic ischemia and reperfusion injury in rats: An experimental researchen_US
dc.typeArticleen_US

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