Protective role of Diospyros lotus on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats

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dc.authoridaydin, muhterem/0000-0002-6494-9229
dc.authoridDOKUMACIOĞLU, EDA/0000-0001-6779-3082
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridSaral, Sinan/0000-0002-0961-1903
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidaydin, muhterem/W-4192-2018
dc.authorwosidDOKUMACIOĞLU, EDA/AAL-5167-2021
dc.authorwosidsaral, özlem/KGK-6267-2024
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidSaral, Sinan/AAE-1125-2022
dc.contributor.authorSaral, S.
dc.contributor.authorOzcelik, E.
dc.contributor.authorCetin, A.
dc.contributor.authorSaral, O.
dc.contributor.authorBasak, N.
dc.contributor.authorAydin, M.
dc.contributor.authorCiftci, O.
dc.date.accessioned2024-08-04T20:41:36Z
dc.date.available2024-08-04T20:41:36Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the protective effect of Diospyros lotus (DL) on cisplatin (CP)-induced testicular damage in male rats. Twenty-eight male rats were randomly divided into four groups: group 1 - control, given isotonic saline solution; group 2 - CP 7mgkg(-1) given intraperitoneally as single dose; group 3 - DL 1000mgkg(-1) per day given orally for 10days; group 4 - CP and DL given together at the same doses. CP caused a significant increase in thiobarbituric acid-reactive substances (TBARS) level and a significant decrease in superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and glutathione (GSH) levels in rats testis tissues compared to the control group. CP caused a significant increase in lipid peroxidation in testis tissues compared to the control group, whereas DL led to a significant increase in SOD and GSH levels. However, there were no statistically significant changes in GPx and CAT levels. In addition, serum testosterone levels, sperm concentration and sperm motility were significantly decreased, but abnormal sperm rate and histological changes were increased with CP. However, these effects of CP on sperm parameters, histological changes and the tissue weights were eliminated by DL treatment. In conclusion, our study showed that the reproductive toxicity caused by CP may be prevented by DL treatment.en_US
dc.identifier.doi10.1111/and.12448
dc.identifier.endpage317en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue3en_US
dc.identifier.pmid26173854en_US
dc.identifier.scopus2-s2.0-84960088031en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage308en_US
dc.identifier.urihttps://doi.org/10.1111/and.12448
dc.identifier.urihttps://hdl.handle.net/11616/97212
dc.identifier.volume48en_US
dc.identifier.wosWOS:000372497600010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectDiospyros lotusen_US
dc.subjectoxidative stressen_US
dc.subjecttesticular damageen_US
dc.titleProtective role of Diospyros lotus on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in ratsen_US
dc.typeArticleen_US

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