Biocompatibility of a new epoxy resin-based root canal sealer in subcutaneous tissue of rat

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dc.authorscopusid55543550800
dc.authorscopusid57193444676
dc.authorscopusid56495479000
dc.authorscopusid46860996700
dc.authorscopusid24544570800
dc.authorscopusid55623262400
dc.contributor.authorSimsek N.
dc.contributor.authorAkinci L.
dc.contributor.authorGecor O.
dc.contributor.authorAlan H.
dc.contributor.authorAhmetoglu F.
dc.contributor.authorTaslidere E.
dc.date.accessioned2024-08-04T20:02:12Z
dc.date.available2024-08-04T20:02:12Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The objective was to evaluate the subcutaneous biocompatibility of two root canal sealers. Materials and Methods: Thirty female rats were distributed into two groups of 15 animals. Each received subcutaneous dorsal implants: Silicone tubes filled with AH Plus or Obtuseal. After the 11th, 14th, and 45th days, tissues were collected for biopsy and fixed and processed for histologic evaluation. Observations of the cellular inflammatory components, such as lymphocytes and macrophages, were made. The data were analyzed using Kruskal-Wallis and Connover tests (P < 0.05). Results: By the 7th day, lymphocyte infiltration increased in both groups (P = 0.0104). However, macrophage infiltration increased only in the AH Plus group (P = 0.0011). By the 14th and 45th days, lymphocyte and macrophage infiltrations were reduced. At the end of the experimental period, no statistically significant differences were found between the AH Plus group and the Obtuseal group (P > 0.05). Conclusion: After 45 days, Obtuseal yielded a satisfactory tissue reaction; it was biocompatible when tested in subcutaneous rat tissue. On the basis of the obtained results, it was concluded that Obtuseal root canal sealer caused a satisfactory tissue reaction as AH plus, because it was biocompatible when tested in the subcutaneous tissue of rats. © 2015 Dental Investigations Society.en_US
dc.identifier.doi10.4103/1305-7456.149635
dc.identifier.endpage35en_US
dc.identifier.issn1305-7456
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84921792953en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://doi.org/10.4103/1305-7456.149635
dc.identifier.urihttps://hdl.handle.net/11616/91513
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDental Investigations Societyen_US
dc.relation.ispartofEuropean Journal of Dentistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiocompatibilityen_US
dc.subjectEndodonticsen_US
dc.subjectEpoxy resin-based sealersen_US
dc.subjectTissue reactionen_US
dc.titleBiocompatibility of a new epoxy resin-based root canal sealer in subcutaneous tissue of raten_US
dc.typeArticleen_US

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