Lysine-Based Two-Component Organogelator: Naproxen Carrier Soft Material

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dc.authoridHayaloglu, Ali Adnan/0000-0002-4274-2729
dc.authorwosidHayaloglu, Ali Adnan/ABF-7063-2020
dc.contributor.authorColak, Mehmet
dc.contributor.authorKaya, Guelsen
dc.contributor.authorAdnan Hayaloglu, Ali
dc.contributor.authorDemirel, Nadir
dc.contributor.authorHosgoeren, Halil
dc.date.accessioned2024-08-04T20:54:56Z
dc.date.available2024-08-04T20:54:56Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe demonstrated that N epsilon -alkanoyl-L-lysine ethyl ester/N-alkanoyl-L-phenylalaninate gelling agents were constructed as a two-component gelling strategy and applied as drug carriers in friendly solvents commonly used. Our designs are expected to have an edge in contrast to the other lipid-based systems due to cheap raw materials, reducing the required amount of carrier, low molecular weight, ease of loading, simple dose adjustability, skin spreadability, and improved drug retention times. It could be loaded with Naproxen (Npx) with a high loading efficiency (up to 100 % as a percentage of gelator) without gel disruption. A complementary in vitro drug release study under specific pH was conducted and performed at different drug and gelator concentrations. These results reveal that the release of Npx from the supramolecular organogels was significantly retarded with increasing organogelator engagement from 0.46 % to 0.92 %, the initial release rate considerably reduced, from 18.75 % to 7.21 %, respectively; that is release rate shows a 2.6-fold decrease; this result showed that the gelator concentration could control drug release. whereas the increasing Npx concentration enhanced it. Altogether, this work produces valuable outcomes, which may be relevant to the pharmaceutical industry, suggesting that new platforms may deliver NSAID ( non-steroidal anti-inflammotory drug) molecules. The study showed controlled release of naproxen was achieved with high loading efficiency (up to 100 % in percent gelator) with different drug and gelator concentrations without damaging the gel structure.imageen_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [113Z142]; University of Dicle research council (DUBAP)en_US
dc.description.sponsorshipThe authors thank The Scientific and Technological Research Council of Turkey (TUBITAK) for financially supporting this research (Project No. 113Z142). And also we are grateful to The University of Dicle research council (DUBAP) for financial support of this work. And also we are greatful to The University of Dicle University Science And Technology Application And Research Center (DUBTAM).en_US
dc.identifier.doi10.1002/slct.202302968
dc.identifier.issn2365-6549
dc.identifier.issue46en_US
dc.identifier.scopus2-s2.0-85179355176en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/slct.202302968
dc.identifier.urihttps://hdl.handle.net/11616/101716
dc.identifier.volume8en_US
dc.identifier.wosWOS:001120897100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistryselecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectControlled drug releaseen_US
dc.subjectlow molecular weight organogelators (LMWOGs)en_US
dc.subjectRheologyen_US
dc.subjectSmall molecule gelling agent (SMGA)en_US
dc.subjectSupramolecular gelsen_US
dc.titleLysine-Based Two-Component Organogelator: Naproxen Carrier Soft Materialen_US
dc.typeArticleen_US

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