Effects of molsidomine on retinal ischemia/reperfusion injury in rabbits

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridPolat, Nihat/0000-0002-1735-1363
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridÖzer, Murat atabey/0000-0003-1807-6911
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidPolat, Nihat/ABI-7316-2020
dc.authorwosidaksungur, zeynep/AAW-2041-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidÖzer, Murat atabey/ISV-0275-2023
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.contributor.authorPolat, N.
dc.contributor.authorOzer, M. A.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorVardi, N.
dc.contributor.authorAksungur, Z.
dc.contributor.authorOzhan, O.
dc.contributor.authorYildiz, A.
dc.date.accessioned2024-08-04T20:44:16Z
dc.date.available2024-08-04T20:44:16Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated the effect of molsidomine (MOL) on ischemia/reperfusion (I/R) injury. Rabbits were assigned to four groups: group 1, sham; group 2, I/R; group 3, MOL treatment for 4days after I/R; group 4, MOL treatment for 1 day before I/R and 3days after I/R. Retinal I/R was produced by elevating the intraocular pressure to 150mm Hg for 60min. Seven days after I/R, the eyes were enucleated. Retinal changes were examined using histochemistry. The levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) also were measured. We found a significant increase in the thickness of the outer nuclear layer of group 3 compared to the other groups. In groups 3 and 4, caspase-3 stained cells in the ganglion cell layer were decreased compared to group 2. We found a significant increase in caspase-3 stained cells in the inner nuclear layer (INL) of group 2 compared to the other groups. We found a significant increase in caspase-3 stained cells in group 3 compared to group 4 in the INL. The MDA level in group 2 was significantly higher than group 1 and MOL significantly decreased MDA levels in groups 3 and 4. We found that MOL protected the retina from I/R injury by enhancing antioxidative effects and inhibiting apoptosis of retinal cells.en_US
dc.identifier.doi10.1080/10520295.2017.1406616
dc.identifier.endpage197en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3en_US
dc.identifier.pmid29323543en_US
dc.identifier.scopus2-s2.0-85040962319en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage188en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2017.1406616
dc.identifier.urihttps://hdl.handle.net/11616/98133
dc.identifier.volume93en_US
dc.identifier.wosWOS:000435663500004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapoptosisen_US
dc.subjectischemiaen_US
dc.subjectreperfusionen_US
dc.subjectmolsidomineen_US
dc.subjectoxidative stressen_US
dc.subjectrabbiten_US
dc.subjectretinaen_US
dc.titleEffects of molsidomine on retinal ischemia/reperfusion injury in rabbitsen_US
dc.typeArticleen_US

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