Neuroprotective effect of mexiletine in the central nervous system of diabetic rats

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoriddurak, mehmet akif akif/0000-0003-0827-2708
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridYucel, Neslihan/0000-0001-5845-2614
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidAltinoz, Eyup/AAM-2378-2020
dc.authorwosiddurak, mehmet akif akif/ABI-1169-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidYucel, Neslihan/ABI-3412-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorAtes, Ozkan
dc.contributor.authorCayli, Suleyman R.
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorYucel, Neslihan
dc.contributor.authorKocak, Ayhan
dc.contributor.authorTarim, Ozcan
dc.contributor.authorDurak, Akif
dc.date.accessioned2024-08-04T20:15:25Z
dc.date.available2024-08-04T20:15:25Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBoth experimental and clinical studies suggests that oxidative stress plays an important role in the pathogenesis of diabetes mellitus type I and type 2. Hyperglycaemia leads to free radical generation and causes neural degeneration. In the present study we investigated the possible neuroprotective effect of mexiletine against streptozotocin-induced hyperglycaemia in the rat brain and spinal cord. 30 adult male Wistar rats were divided into three groups: control, diabetic, and diabetic-mexiletine treated group. Diabetes mellitus was induced by a single injection of streptozotocin (60 mg/kg body weight). Mexiletine (50 mg/kg) was injected intraperitoneally every day for six weeks. After 6 weeks the brain, brain stem and cervical spinal cord of the rats were removed and the hippocampus, cortex, cerebellum, brain stem and spinal cord were dissected for biochemical analysis (the level of Malondialdehide [MDA], Nitric Oxide [NO], Reduced Glutathione [GSH], and Xanthine Oxidase [XO] activity). MDA, XO and NO levels in the hippocampus, cortex, cerebellum, brain stem and spinal cord of the diabetic group increased significantly, when compared with control and mexiletine groups (P < 0.05). GSH levels in the hippocampus, cortex, cerebellum, brain stem and spinal cord of the diabetic group decreased significantly when compared with control and mexiletine groups (P < 0.05). This study demonstrates that mexiletine protects the neuronal tissue against the diabetic oxidative damage.en_US
dc.identifier.doi10.1007/s11010-005-9102-6
dc.identifier.endpage131en_US
dc.identifier.issn0300-8177
dc.identifier.issn1573-4919
dc.identifier.issue1-2en_US
dc.identifier.pmid16541198en_US
dc.identifier.scopus2-s2.0-33646236111en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage125en_US
dc.identifier.urihttps://doi.org/10.1007/s11010-005-9102-6
dc.identifier.urihttps://hdl.handle.net/11616/94372
dc.identifier.volume286en_US
dc.identifier.wosWOS:000238614000016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular and Cellular Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcentral nervous systemen_US
dc.subjectdiabetes mellitusen_US
dc.subjectmexiletineen_US
dc.subjectlipid peroxidationen_US
dc.subjectoxidative damageen_US
dc.subjectstreptozotocinen_US
dc.titleNeuroprotective effect of mexiletine in the central nervous system of diabetic ratsen_US
dc.typeArticleen_US

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