Central MOTS-c infusion affects reproductive hormones in obese and non-obese rats

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dc.contributor.authorOzturk, Dilara Altay
dc.contributor.authorErden, Yavuz
dc.contributor.authorTekin, Suat
dc.date.accessioned2024-08-04T20:55:09Z
dc.date.available2024-08-04T20:55:09Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMOTS-c, a mitochondrial-derived peptide, acts as a systemic hormone and MOTS-c level is inversely correlated with markers of obesity. Obesity is a risk factor for male reproductive physiology and is expressed as an important cause of infertility. In this study, we aimed to determine the effects of MOTS-c, which has been proven in the hypothalamus and testicles, on the actors involved in the reproductive axis. In the study, 80 male Wistar-Albino rats were divided into two main groups, obese and non-obese (n = 40). Rats in the first main group were fed with fatty diet feed and obesity was induced. The second main group was fed with normal diet feed. Each main group was divided into 4 subgroups (Control, Sham, 10 and 100 mu M MOTS-c). The lateral ventricles of the animals in the treatment groups were infused with 10 and 100 mu M MOTS-c (solvent in Sham group) for 14 days. At the end of the experiment, hypothalamic Gonadotropin-Releasing Hormone (GnRH) gene expression level, serum testosterone, Luteinizing hormone (LH) and Follicle stimulating hormone (FSH) levels were determined. MOTS-c infusion caused an increase in GnRH mRNA, protein expression levels and serum testosterone, LH and FSH levels in obese and non-obese rats (p < 0.05). MOTS-c administration more significantly upregulated hormone levels in non-obese rats (p < 0.05). MOTS-c administration increases these hormones, suggesting that MOTS-c may stimulate the reproductive axis. Our results reveal that MOTS-c plays a role in the central regulation of reproduction, as well as causes increased LH, FSH and testosterone release.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [116S744]; Inonu University Scientific Research Projects Unit (BAP) [TYL-2020-2175]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK; Project No: 116S744) and Inonu University Scientific Research Projects Unit (BAP; Project No: TYL-2020-2175) .en_US
dc.identifier.doi10.1016/j.neulet.2024.137722
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.pmid38462167en_US
dc.identifier.scopus2-s2.0-85187573868en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2024.137722
dc.identifier.urihttps://hdl.handle.net/11616/101875
dc.identifier.volume826en_US
dc.identifier.wosWOS:001203198800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGnRHen_US
dc.subjectLHen_US
dc.subjectFSHen_US
dc.subjectMOTS-cen_US
dc.subjectObesityen_US
dc.subjectTestosteroneen_US
dc.titleCentral MOTS-c infusion affects reproductive hormones in obese and non-obese ratsen_US
dc.typeArticleen_US

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