The IL-8 Gene Polymorphisms in Behcet's Disease Observed in Denizli Province of Turkey

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dc.authoridOZTURK, Onur/0000-0003-3404-4135
dc.authoridTasli, Levent/0000-0002-5433-4394
dc.authoridArikan, Sanem/0000-0001-7987-9078
dc.authorwosidOZTURK, Onur/HLH-4990-2023
dc.authorwosidTasli, Levent/AAD-6575-2022
dc.authorwosidDuygulu, Şeniz/AAT-8438-2020
dc.authorwosidArıkan, Sanem/ABI-6170-2020
dc.authorwosidATALAY, AYFER/HKO-1963-2023
dc.authorwosidDuygulu, Şeniz/HIR-2895-2022
dc.contributor.authorAtalay, Ayfer
dc.contributor.authorArikan, Sanem
dc.contributor.authorOzturk, Onur
dc.contributor.authorOncu, Mustafa
dc.contributor.authorTasli, Mehmet Levent
dc.contributor.authorDuygulu, Seniz
dc.contributor.authorAtalay, Erol Omer
dc.date.accessioned2024-08-04T20:41:42Z
dc.date.available2024-08-04T20:41:42Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBehcet's disease is a multisystemic inflammatory disorder as a triad of symptoms including recurrent oral and genital aphthous ulceration and uveitis with unknown pathogenesis. IL-8, a proinflammatory cytokine, has been found increased in the active stage of BD. DNA samples were obtained from 88 patients with BD and 112 healthy control subjects in Denizli province of Turkey. All genotyping experiments of SNPs in IL-8 gene were performed using polymerase chain reaction-restriction fragment polymorphism. We found that IL-8 -845 T > C and -738 T > A sites are non-polymorphic. There were no differences in the polymorphisms of IL-8 + 396 G/T, + 781 C/T, and + 1633 C/T sites except IL-8 -251 T > A in between patients and healthy controls. Analysis of IL-8 polymorphisms indicates that the distribution of frequencies seems to be associated with -251 T > A and gender, -251 T > A and erythema nodosum, -251 T > A and ocular involvement, + 781 C > T and erythema nodosum, + 396 G > T and pathergy positivity, and + 1633 C > T and papulopustular lesion. We demonstrated that the frequencies of IL-8 haplotypes were significantly different with BD patients than control group. We found that the distribution of IL-8 haplotypes was significantly different with genital ulcers, ocular involvement, positive pathergy test, erythema nodosum, papulopustular lesions, and arthritis with BD patients than healthy control individuals. Our study suggests that IL-8 gene polymorphisms may affect susceptibility to BD and increase the risk of developing disease. In order to confirm and assess the association of IL-8 and other cytokine gene polymorphisms in the pathophysiology of BD, large cohort studies are needed.en_US
dc.description.sponsorshipTUBITAK [SBAG-2388, 113S163]en_US
dc.description.sponsorshipThis study was supported under the framework of the TUBITAK projects, Project numbers SBAG-2388 and 113S163.en_US
dc.identifier.doi10.3109/08820139.2016.1153652
dc.identifier.endpage311en_US
dc.identifier.issn0882-0139
dc.identifier.issn1532-4311
dc.identifier.issue4en_US
dc.identifier.pmid27101127en_US
dc.identifier.scopus2-s2.0-84964514066en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage298en_US
dc.identifier.urihttps://doi.org/10.3109/08820139.2016.1153652
dc.identifier.urihttps://hdl.handle.net/11616/97293
dc.identifier.volume45en_US
dc.identifier.wosWOS:000374996100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofImmunological Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjecthaplotypeen_US
dc.subjectinterleukin-8en_US
dc.subjectpolymorphismsen_US
dc.titleThe IL-8 Gene Polymorphisms in Behcet's Disease Observed in Denizli Province of Turkeyen_US
dc.typeArticleen_US

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