Effects of ciprofloxacin and quercetin on fetal brain development: a biochemical and histopathological study

Basit Öğe Kaydı
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridTürköz, Yusuf/0000-0001-5401-0720;
dc.authorwosidÇETİN, AYMELEK/AAA-7420-2021
dc.authorwosidDogan, Zumrut yılmaz/V-5131-2018
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidDoğan, Zümrüt/GQP-2535-2022
dc.contributor.authorDogan, Zumrut
dc.contributor.authorCetin, Aymelek
dc.contributor.authorElibol, Ebru
dc.contributor.authorVardi, Nigar
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2024-08-04T20:44:16Z
dc.date.available2024-08-04T20:44:16Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Teratogens cause birth defects and malformations while human development is being completed. In pregnancy, urinary tract infection (UTI) is a common health problem caused by bacteria. The fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin, and gemifloxacin can treat various types of bacterial infections successfully. The aim of this study is to determine whether the use of ciprofloxacin during pregnancy causes oxidative stress on brain tissues of the fetus, and whether quercetin contributes to prevent this damage if stress has already occurred.Materials and methods: In our study, 22 young female Wistar albino rats weighing 250g were used. Rats were mated overnight in separate plastic cages. Female rats were regarded as pregnant when a vaginal plug was observed, and these were divided into four groups of control, ciprofloxacin, quercetin, and cipro+quercetin. Two daily i.p. 20mg/kg doses of ciprofloxacin were administered to ciprofloxacin group between 7 and 17 d of pregnancy. Throughout the study, daily (20 d) 20mg/kg quercetin was dissolved in corn oil and administered to the quercetin group by oral gavage. Rats were fed ad libitum throughout the study. Fetuses were taken by C-section on the 20th day of pregnancy. Thereafter, the brain tissues were subjected to histological assessments and biochemical analyzes.Results: The experimental groups were compared with the control group; ciprofloxacin affected fetal development, especially caused damage to neurons in brain tissue and cause hemorrhagic defects. And also, it was determined that many parameters were affected such as antioxidant parameters, enzyme levels and levels of malondialdehyde (MDA) (a marker of lipid peroxidation). Quercetin is a member of flavonoid with strong antioxidant properties, and our results indicate that the use of ciprofloxacin in pregnancy can result damage to fetal brain tissue.Conclusions: Unlike these results when some parameters are evaluated it is understood that this harmful effects suppressed by quercetin.en_US
dc.description.sponsorshipInonu University Research Fund [INU-BAP 2011/163]en_US
dc.description.sponsorshipThis research was supported by Inonu University Research Fund (INU-BAP 2011/163).en_US
dc.identifier.doi10.1080/14767058.2017.1418222
dc.identifier.endpage1791en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue11en_US
dc.identifier.pmid29241384en_US
dc.identifier.scopus2-s2.0-85041125922en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1783en_US
dc.identifier.urihttps://doi.org/10.1080/14767058.2017.1418222
dc.identifier.urihttps://hdl.handle.net/11616/98134
dc.identifier.volume32en_US
dc.identifier.wosWOS:000461607900006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrainen_US
dc.subjectciprofloxacinen_US
dc.subjectfetal developmenten_US
dc.subjectquercetinen_US
dc.subjectraten_US
dc.titleEffects of ciprofloxacin and quercetin on fetal brain development: a biochemical and histopathological studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu