Association of CagA and VacA presence with ulcer and non-ulcer dyspepsia in a Turkish population
Küçük Resim Yok
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Baishideng Publishing Group Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
AIM: The mostly known genotypic virulence features, of H. pylori are cytotoxin associated gene A (cagA) and Vacuolating cytotoxin gene A (VacA). We investigated the association of these major virulence factors with ulcer an non-ulcer dyspepsia in our region. METHODS: One hundred and forty two dyspeptic patients were studied (average age 44.8+/-15.9 years, range 15-87 years, 64 males and 78 females). Antral and corpus biopsies were taken for detecting and genotyping of H. pylori. 107 patients who were H. pylori positive by histological assessment were divided into three groups according to endoscopic findings: Duodenal ulcer (DU), gastric ulcer (GU) and non-ulcer dyspepsia (NUD). The polymerase chain reaction (PCR) was used to detect CagA and VacA genes of H. pylori using specific primers. RESULTS: H. pylori was isolated from 75.4 % (107/142) of the patients. Of the 107 patients, 66 (61.7 %) were cagA- positive and 82 (76.6 %) were VacA-positive. CagA gene was positively associated with DU and GU (P<0.01, P<0.02), but not with NUD (P>0.05). Although VacA positivity in ulcer patients was higher than that in NUD group, the difference was not statistically significant (P>0.05). CONCLUSION: There is a significantly positive association between CagA genes and DU and GU. The presence of VacA is not a predictive marker for DU, GU, and NUD in our patients.
Açıklama
Anahtar Kelimeler
Helicobacter-Pylori Antigens, Vacuolating Cytotoxin Gene, Peptic-Ulcer, Virulence Factors, Duodenal-Ulcer, Pathogenicity Island, Serological Response, Infected Patients, Gastric Lymphoma, Serum Antibodies
Kaynak
World Journal of Gastroenterology
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
9
Sayı
7
