Phenethyl isothiocyanate protects against cyclophosphamide-induced nephrotoxicity via nuclear factor E2-related factor 2 pathway in rats

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dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authorwosidAtici, Bugrahan/IAQ-3831-2023
dc.authorwosidSatilmis, Basri/JBR-9078-2023
dc.contributor.authorUyumlu, Ayse Burcin
dc.contributor.authorSatilmis, Basri
dc.contributor.authorAtici, Bugrahan
dc.contributor.authorTaslidere, Asli
dc.date.accessioned2024-08-04T20:53:21Z
dc.date.available2024-08-04T20:53:21Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPhenethyl isothiocyanate (PEITC), a secondary metabolite in Cruciferous plants, exerts chemopreventive and antioxidant effects. However, its therapeutic potential in cyclophosphamide (CP)-induced nephrotoxicity is not clear. So, we focused to research on the effect of PEITC against renal toxicity caused by CP and its relationship to the Nrf2 signaling mechanism. Thirty female Wistar albino rats were allocated to three groups: control (n = 10), CP (n = 10), and PEITC-pretreated group (150 mu mol/kg b.w. orally; n = 10). The antioxidant enzyme activities and levels of malondialdehyde (MDA), sirtuin 1 (SIRT1), glutathione-S-transferase (GST), nuclear factor E2-related factor 2 (Nrf2), nuclear factor kappa B (NF-kappa B), serum urea, and creatinine (Cr) were measured. In the CP group, serum urea and Cr, MDA, and NF-kappa B levels have risen, and the activities of antioxidant enzymes and SIRT1, Nrf2, and GST levels have reduced significantly (P < 0.05). PEITC diminished levels of Cr, urea, MDA, and NF-kappa B while it enhanced antioxidant enzyme activities and GST, Nrf2, and SIRT1 levels significantly (P < 0.05). Pretreatment with PEITC ameliorated kidney tissue injury. The renal protective effect of the PEITC was supported by the histological analysis of the kidney. PEITC prevented CP-induced nephrotoxicity by decreasing oxidative damage through Nrf2 and SIRT1 activation and NF-kappa B inhibition. Therefore, we have suggested that PEITC may be a useful agent for protection against CP-induced renal injury.en_US
dc.description.sponsorshipScientific Research Projects Unit of Inoenue University [2019-1901]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was funded by the Scientific Research Projects Unit of Inoenue University (grant number 2019-1901).en_US
dc.identifier.doi10.1177/15353702221139206
dc.identifier.endpage164en_US
dc.identifier.issn1535-3702
dc.identifier.issn1535-3699
dc.identifier.issue2en_US
dc.identifier.pmid36598044en_US
dc.identifier.scopus2-s2.0-85146095188en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://doi.org/10.1177/15353702221139206
dc.identifier.urihttps://hdl.handle.net/11616/101109
dc.identifier.volume248en_US
dc.identifier.wosWOS:000908255300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofExperimental Biology and Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCyclophosphamideen_US
dc.subjectnephrotoxicityen_US
dc.subjectNrf2en_US
dc.subjectphenethyl isothiocyanateen_US
dc.subjectsirtuin1en_US
dc.titlePhenethyl isothiocyanate protects against cyclophosphamide-induced nephrotoxicity via nuclear factor E2-related factor 2 pathway in ratsen_US
dc.typeArticleen_US

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