Effects of caffeic acid phenethyl ester use and inhibition of p42/44 MAP kinase signal pathway on caveolin 1 gene expression and antioxidant system in chronic renal failure model of rats

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dc.authorwosidDurhan, Merve/JOK-8847-2023
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorOzen, Hasan
dc.contributor.authorDurhan, Merve
dc.contributor.authorTunc, Selahattin
dc.contributor.authorKose, Evren
dc.date.accessioned2024-08-04T20:50:57Z
dc.date.available2024-08-04T20:50:57Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractEffects of Caffeic acid phenethyl ester (CAPE) and/or PD98059 (PD) on the gene expression of Caveolin-1 (CAV1) and reduced glutathione (GSH), malondialdehyde (MDA), copper-zinc superoxide dismutase (CuZn-SOD), and catalase (CAT) enzyme activities were investigated in an experimental chronic renal failure model in rats. Eighty Wistar rats were divided into eight groups for a 28-day study: Control, CsA (Cyclosporine A), CsA-V (CsA solvent), CsA + PD (CsA + PD98059), CsA + PD + CAPE, CsA + CAPE, CAPE-V (CAPE solvent), and PD-V (PD98059 solvent). Serum blood urea nitrogen and creatinine levels, as well as histopathological findings indicated the development of renal failure in the CsA group. Kidney GSH levels decreased while MDA levels, CuZn-SOD, and CAT activities increased significantly in the CsA group compared to control indicating oxidative stress. CAV1 gene expression significantly decreased in the CsA group compared to the control. PD98059 and CAPE applications made positive improvements in the levels of the parameters investigated. PD98059 and CAPE applications in CsA given animals increased GSH and CAV1 gene expressions and decreased CuZn-SOD and CAT levels compared to the CsA group. In conclusion, it was shown that PD98059 and CAPE could attenuate the effects of chronic renal failure, and CAV1 is suggested as a therapeutic target and the inhibition of the p44/42 MAPK pathway may be a new approach for the treatment of renal degenerations.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK, SBAG Project) [113S915]en_US
dc.description.sponsorshipThis research was supported by The Scientific and Technological Research Council of Turkey (TUBITAK, SBAG Project, No: 113S915).en_US
dc.identifier.doi10.1080/01480545.2021.2016043
dc.identifier.endpage208en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue2en_US
dc.identifier.pmid34957889en_US
dc.identifier.scopus2-s2.0-85121864089en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage197en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2021.2016043
dc.identifier.urihttps://hdl.handle.net/11616/100384
dc.identifier.volume46en_US
dc.identifier.wosWOS:000734828700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic renal failureen_US
dc.subjectcaveolinen_US
dc.subjectcyclosporine Aen_US
dc.subjectPD98059en_US
dc.subjectCAPEen_US
dc.titleEffects of caffeic acid phenethyl ester use and inhibition of p42/44 MAP kinase signal pathway on caveolin 1 gene expression and antioxidant system in chronic renal failure model of ratsen_US
dc.typeArticleen_US

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