Melatonin and CAPE are Able to Prevent the Liver from Oxidative Damage in Rats: An Ultrastructural and Biochemical Study

Basit Öğe Kaydı
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorIraz, Mustafa
dc.contributor.authorAtes, Burhan
dc.contributor.authorGul, Mehmet
dc.date.accessioned2024-08-04T20:35:52Z
dc.date.available2024-08-04T20:35:52Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe liver continuously produces free radicals and reactive oxygen species (ROS) as part of metabolic process. These free radicals are neutralized by an elaborate antioxidant defense system consisting of enzymes and numerous nonenzymatic antioxidants like flavonoids. In this study, we have evaluated effects of melatonin and caffeic acid phenethyl ester (CAPE) to young and aged rat liver. Aging-related hepatic changes examined by light and electron microscopy and biochemical methods. Melatonin and CAPE decreased tissue malondialdehyde (MDA) levels in aged rats. Melatonin elevated tissue glutathione peroxidase (GSH-Px) activity and tGSH level, whereas CAPE elevated tissue catalase activity in aged rats. This study demonstrates that both melatonin and CAPE are beneficial in delaying age-related hepatocellular changes. Melatonin and CAPE supplementation in older ages may support liver to protect itself from various damaging agents including infectious agents and toxins.en_US
dc.identifier.doi10.3109/01913123.2011.647262
dc.identifier.endpage178en_US
dc.identifier.issn0191-3123
dc.identifier.issn1521-0758
dc.identifier.issue3en_US
dc.identifier.pmid22559044en_US
dc.identifier.scopus2-s2.0-84860668672en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage171en_US
dc.identifier.urihttps://doi.org/10.3109/01913123.2011.647262
dc.identifier.urihttps://hdl.handle.net/11616/95644
dc.identifier.volume36en_US
dc.identifier.wosWOS:000303607900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofUltrastructural Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgingen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectliveren_US
dc.subjectmelatoninen_US
dc.subjectoxidative stressen_US
dc.titleMelatonin and CAPE are Able to Prevent the Liver from Oxidative Damage in Rats: An Ultrastructural and Biochemical Studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu